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- W2050890098 abstract "Chronic lymphocytic leukemia (CLL) is an indolent disorder with a highly variable course whose clinical features arise through the accumulation of tumor cells in the bone marrow, blood and secondary lymphoid tissue. While hematopoietic failure may occur in those with advanced disease, for the majority it is immune dysfunction, manifested as susceptibility to infection or autoimmunity, which dominates the clinical picture. Both the disease and its treatment may affect the number of normal cells in the innate and adaptive immune systems, however, it is clear that there are also more subtle qualitative defects which presumably arise either through contact with the expanded neoplastic B cell compartment or because of the secretion of immunomodulatory cytokines. A variety of functional defects in T cells from patients with CLL have been reported including, reduction in activation-induced CD40L expression1 and abnormalities of gene expression affecting the differentiation of CD4 cells and cytoskeletal function and vesicle transport in CD8 cells.2 Although these abnormalities were shown to arise through contact with the malignant clone it is clear that soluble mediators may also play a role, as we have previously shown in myeloid malignancies.3 In the present study, we sought to characterize and identify soluble immunomodulatory factors in CLL since these might lend themselves to therapeutic intervention." @default.
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- W2050890098 date "2007-11-01" @default.
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- W2050890098 title "Tumor-derived IL-6 may contribute to the immunological defect in CLL" @default.
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- W2050890098 doi "https://doi.org/10.1038/sj.leu.2405015" @default.
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