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• W2050917405 abstract "The transbilayer movement (flip-flop) of 7-nitrobenz-2-oxa-1,3-diazol-4-yl phosphatidylethanolamine (NBD-PE) in phosphatidylcholine (PC) membranes containing various acyl chains was measured by dithionite quenching of NBD fluorescence. Of specific interest was docosahexaenoic acid (DHA), the longest and most unsaturated acyl chain commonly found in membranes. This molecule represents the extreme example of a family of important fatty acids known as omega-3s and has been clearly demonstrated to alter membrane structure and function. One important property that has yet to be reported is the effect of DHA on membrane phospholipid flip-flop. This study demonstrates that as the number of double bonds in the fatty acyl chains comprising the membrane increases, so does the rate of flip-flop of the NBD-PE probe. The increase is particularly marked in the presence of DHA. Half-lives t1/2 of 0.29 and 0.086 h describe the process in 1-stearoyl-2-docosahexaenoylphosphatidylcholine and 1,2-didocosahexaenoylphosphatidylcholine, respectively, whereas in 1-stearoyl-2-oleoylphosphatidylcholine t1/2=11.5h. Enhanced permeability to dithionite with increasing unsaturation was also indicated by our results. We conclude that PC membranes containing DHA support faster flip-flop and permeability rates than those measured for other less-unsaturated PCs." @default.
• W2050917405 created "2016-06-24" @default.
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• W2050917405 date "2003-06-01" @default.
• W2050917405 modified "2023-09-30" @default.
• W2050917405 title "Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes" @default.
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• W2050917405 doi "https://doi.org/10.1016/s0003-9861(03)00159-0" @default.
• W2050917405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12745257" @default.
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