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• W2050934420 abstract "We directed the human natural killer (NK) cell line YT by gene transfer of a humanized chimeric immunoglobulin T cell receptor to CD33, a marker on myeloid leukemias. The chimeric receptor was generated using a CD33 specific single-chain Fv (scFv) fragment based on the humanized antibody HuM195, the human IgG1 Fc domains and the human CD3 ζ signal chain. YT cells transfected by electroporation with the chimeric receptor gene specifically lysed the acute myeloid leukemia (AML) cell line KG1. This gene-modified NK cell line available in unlimited source could be an attractive tool in immunotherapy." @default.
• W2050934420 created "2016-06-24" @default.
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• W2050934420 date "2005-03-01" @default.
• W2050934420 modified "2023-10-03" @default.
• W2050934420 title "Specific targeting of CD33+ leukemia cells by a natural killer cell line modified with a chimeric receptor" @default.
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• W2050934420 doi "https://doi.org/10.1016/j.leukres.2004.07.005" @default.
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