FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050934472> ?p ?o ?g. }

• W2050934472 endingPage "58" @default.
• W2050934472 startingPage "42" @default.
• W2050934472 abstract "Ten years ago Frank McCormick proposed dl1520 as an oncolytic adenovirus. Although great as an inspiration for better oncolytic viruses it was far from a good product. As Onyx-015, it underwent a wish-fulfilling clinical development program seizing the opportunity left by its p53-targeted non-replicative counterpart Ad-p53. Now, facing a skeptical environment, more selective and potent oncolytic adenoviruses await their clinical opportunity. However, advance in key issues remains elusive, such as, selectivity or retargeting at the level of cell receptors to improve pharmacokinetics. Preclinical models and a few clinical data on biodistribution show that only a minimal proportion of the injected dose reaches the tumors after systemic administration. Once in the tumor, the virus must overcome barriers to efficient spread imposed by stroma and immune responses. Arming the oncolytic virus with transgenes is a natural combination of virotherapy and gene therapy strategies. Transgenes that increase virus production or cellular spread may help to overcome these barriers. Cytotoxic transgenes can help to eliminate tumor cells but need to be compatible with efficient virus replication. These challenges require a careful approach to clinical development and a great deal of collaboration to launch clinical tests with a virus backbone that contains intellectual property from multiple sources." @default.
• W2050934472 created "2016-06-24" @default.
• W2050934472 creator A5084444653 @default.
• W2050934472 date "2007-02-01" @default.
• W2050934472 modified "2023-10-17" @default.
• W2050934472 title "Cancer selective adenoviruses" @default.
• W2050934472 cites W1491631791 @default.
• W2050934472 cites W1582164157 @default.
• W2050934472 cites W1970247544 @default.
• W2050934472 cites W1983766005 @default.
• W2050934472 cites W1986213970 @default.
• W2050934472 cites W1998071815 @default.
• W2050934472 cites W1999160447 @default.
• W2050934472 cites W2003850700 @default.
• W2050934472 cites W2008996723 @default.
• W2050934472 cites W2015560811 @default.
• W2050934472 cites W2016080258 @default.
• W2050934472 cites W2017576006 @default.
• W2050934472 cites W2024224467 @default.
• W2050934472 cites W2026796660 @default.
• W2050934472 cites W2027178820 @default.
• W2050934472 cites W2028074588 @default.
• W2050934472 cites W2034314779 @default.
• W2050934472 cites W2036581805 @default.
• W2050934472 cites W2043400006 @default.
• W2050934472 cites W2047391267 @default.
• W2050934472 cites W2061448062 @default.
• W2050934472 cites W2063172838 @default.
• W2050934472 cites W2073134590 @default.
• W2050934472 cites W2076133729 @default.
• W2050934472 cites W2082984369 @default.
• W2050934472 cites W2083814515 @default.
• W2050934472 cites W2085649860 @default.
• W2050934472 cites W2093915566 @default.
• W2050934472 cites W2098374956 @default.
• W2050934472 cites W2098472306 @default.
• W2050934472 cites W2099794736 @default.
• W2050934472 cites W2110592777 @default.
• W2050934472 cites W2111610031 @default.
• W2050934472 cites W2113127264 @default.
• W2050934472 cites W2117160925 @default.
• W2050934472 cites W2119498791 @default.
• W2050934472 cites W2140442649 @default.
• W2050934472 cites W2144678424 @default.
• W2050934472 cites W2148872113 @default.
• W2050934472 cites W2169575465 @default.
• W2050934472 cites W2180993978 @default.
• W2050934472 cites W2325631985 @default.
• W2050934472 cites W2413956401 @default.
• W2050934472 doi "https://doi.org/10.1016/j.mam.2006.12.002" @default.
• W2050934472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17300834" @default.
• W2050934472 hasPublicationYear "2007" @default.
• W2050934472 type Work @default.
• W2050934472 sameAs 2050934472 @default.
• W2050934472 citedByCount "106" @default.
• W2050934472 countsByYear W20509344722012 @default.
• W2050934472 countsByYear W20509344722013 @default.
• W2050934472 countsByYear W20509344722014 @default.
• W2050934472 countsByYear W20509344722015 @default.
• W2050934472 countsByYear W20509344722016 @default.
• W2050934472 countsByYear W20509344722017 @default.
• W2050934472 countsByYear W20509344722018 @default.
• W2050934472 countsByYear W20509344722021 @default.
• W2050934472 countsByYear W20509344722022 @default.
• W2050934472 countsByYear W20509344722023 @default.
• W2050934472 crossrefType "journal-article" @default.
• W2050934472 hasAuthorship W2050934472A5084444653 @default.
• W2050934472 hasConcept C102230213 @default.
• W2050934472 hasConcept C104317684 @default.
• W2050934472 hasConcept C111599444 @default.
• W2050934472 hasConcept C159047783 @default.
• W2050934472 hasConcept C2522874641 @default.
• W2050934472 hasConcept C49744831 @default.
• W2050934472 hasConcept C502942594 @default.
• W2050934472 hasConcept C55493867 @default.
• W2050934472 hasConcept C70721500 @default.
• W2050934472 hasConcept C71924100 @default.
• W2050934472 hasConcept C82210918 @default.
• W2050934472 hasConcept C86803240 @default.
• W2050934472 hasConceptScore W2050934472C102230213 @default.
• W2050934472 hasConceptScore W2050934472C104317684 @default.
• W2050934472 hasConceptScore W2050934472C111599444 @default.
• W2050934472 hasConceptScore W2050934472C159047783 @default.
• W2050934472 hasConceptScore W2050934472C2522874641 @default.
• W2050934472 hasConceptScore W2050934472C49744831 @default.
• W2050934472 hasConceptScore W2050934472C502942594 @default.
• W2050934472 hasConceptScore W2050934472C55493867 @default.
• W2050934472 hasConceptScore W2050934472C70721500 @default.
• W2050934472 hasConceptScore W2050934472C71924100 @default.
• W2050934472 hasConceptScore W2050934472C82210918 @default.
• W2050934472 hasConceptScore W2050934472C86803240 @default.
• W2050934472 hasFunder F4320321764 @default.
• W2050934472 hasFunder F4320322606 @default.
• W2050934472 hasFunder F4320333067 @default.
• W2050934472 hasIssue "1" @default.
• W2050934472 hasLocation W20509344721 @default.
• W2050934472 hasLocation W20509344722 @default.
• W2050934472 hasOpenAccess W2050934472 @default.

• next