Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050941607> ?p ?o ?g. }
- W2050941607 endingPage "196" @default.
- W2050941607 startingPage "187" @default.
- W2050941607 abstract "Cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) plays a key role in restraining the adaptive immune response of T-cells towards a variety of antigens including tumor associated antigens (TAAs). The blockade of this immune checkpoint elicits an effective anticancer immune response in a range of preclinical models, suggesting that naturally occurring (or therapeutically induced) TAA specific lymphocytes need to be “unleashed” in order to properly fight against malignant cells. Therefore, investigators have tested this therapeutic hypothesis also in humans: the favorable results obtained with this strategy in patients with advanced cutaneous melanoma are revolutionizing the management of this highly aggressive disease and are fueling new enthusiasm on cancer immunotherapy in general. Here we summarize the biology of CTLA-4, overview the experimental data supporting the rational for targeting CTLA-4 to treat cancer and review the main clinical findings on this novel anticancer approach. Moreover, we critically discuss the current challenges and potential developments of this promising field of cancer immunotherapy." @default.
- W2050941607 created "2016-06-24" @default.
- W2050941607 creator A5009562018 @default.
- W2050941607 creator A5010324991 @default.
- W2050941607 date "2013-12-01" @default.
- W2050941607 modified "2023-10-11" @default.
- W2050941607 title "CTLA-4 blockade and the renaissance of cancer immunotherapy" @default.
- W2050941607 cites W1483726034 @default.
- W2050941607 cites W1499850570 @default.
- W2050941607 cites W1519521580 @default.
- W2050941607 cites W1550301398 @default.
- W2050941607 cites W1916595094 @default.
- W2050941607 cites W1918895132 @default.
- W2050941607 cites W1965494873 @default.
- W2050941607 cites W1966073503 @default.
- W2050941607 cites W1966483230 @default.
- W2050941607 cites W1971986799 @default.
- W2050941607 cites W1973667304 @default.
- W2050941607 cites W1974176583 @default.
- W2050941607 cites W1977607846 @default.
- W2050941607 cites W1978741561 @default.
- W2050941607 cites W1981528932 @default.
- W2050941607 cites W1981784297 @default.
- W2050941607 cites W1982889687 @default.
- W2050941607 cites W1984484036 @default.
- W2050941607 cites W1984677655 @default.
- W2050941607 cites W1989823046 @default.
- W2050941607 cites W1993560480 @default.
- W2050941607 cites W1996390968 @default.
- W2050941607 cites W1997286876 @default.
- W2050941607 cites W2002028156 @default.
- W2050941607 cites W2002250199 @default.
- W2050941607 cites W2008452038 @default.
- W2050941607 cites W2012815184 @default.
- W2050941607 cites W2013043293 @default.
- W2050941607 cites W2014372297 @default.
- W2050941607 cites W2014545440 @default.
- W2050941607 cites W2015085911 @default.
- W2050941607 cites W2020988840 @default.
- W2050941607 cites W2024167344 @default.
- W2050941607 cites W2028554440 @default.
- W2050941607 cites W2029208213 @default.
- W2050941607 cites W2036383793 @default.
- W2050941607 cites W2041672829 @default.
- W2050941607 cites W2042630756 @default.
- W2050941607 cites W2043812762 @default.
- W2050941607 cites W2043843121 @default.
- W2050941607 cites W2044835625 @default.
- W2050941607 cites W2046353721 @default.
- W2050941607 cites W2046739604 @default.
- W2050941607 cites W2046834643 @default.
- W2050941607 cites W2048073154 @default.
- W2050941607 cites W2050135580 @default.
- W2050941607 cites W2053248202 @default.
- W2050941607 cites W2060910588 @default.
- W2050941607 cites W2061071534 @default.
- W2050941607 cites W2063192133 @default.
- W2050941607 cites W2064058305 @default.
- W2050941607 cites W2066671159 @default.
- W2050941607 cites W2068971398 @default.
- W2050941607 cites W2069640477 @default.
- W2050941607 cites W2070059266 @default.
- W2050941607 cites W2070590957 @default.
- W2050941607 cites W2071483270 @default.
- W2050941607 cites W2075819066 @default.
- W2050941607 cites W2077701601 @default.
- W2050941607 cites W2078081644 @default.
- W2050941607 cites W2087850260 @default.
- W2050941607 cites W2094366129 @default.
- W2050941607 cites W2095826876 @default.
- W2050941607 cites W2096825083 @default.
- W2050941607 cites W2097995306 @default.
- W2050941607 cites W2098005365 @default.
- W2050941607 cites W2098414192 @default.
- W2050941607 cites W2099613594 @default.
- W2050941607 cites W2100158834 @default.
- W2050941607 cites W2105017308 @default.
- W2050941607 cites W2105958268 @default.
- W2050941607 cites W2109465910 @default.
- W2050941607 cites W2109653150 @default.
- W2050941607 cites W2112069616 @default.
- W2050941607 cites W2112506009 @default.
- W2050941607 cites W2114239197 @default.
- W2050941607 cites W2116169737 @default.
- W2050941607 cites W2116364705 @default.
- W2050941607 cites W2116583846 @default.
- W2050941607 cites W2117089606 @default.
- W2050941607 cites W2119198740 @default.
- W2050941607 cites W2119895292 @default.
- W2050941607 cites W2121498145 @default.
- W2050941607 cites W2122951893 @default.
- W2050941607 cites W2123264723 @default.
- W2050941607 cites W2123363005 @default.
- W2050941607 cites W2128542677 @default.
- W2050941607 cites W2130822830 @default.
- W2050941607 cites W2133911621 @default.
- W2050941607 cites W2134638467 @default.
- W2050941607 cites W2136746908 @default.