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- W2050945462 abstract "The influence of clomiphene citrate was tested in 206 women suffering from menorrhagia following the insertion of an intrauterine device (IUD). Eighty-three percent felt relief during the therapy, 10% did not benefit and 7% complained of a worsening of their symptoms. Among the women who felt an improvement, 85% responded to the 250 mg/cycle dosage, and 15% required the 350 mg/cycle dosage. Women with shortened menstrual cycles required the higher dose treatment, i.e. 350 mg, compared with women with normal cycles (36% vs. 28%, respectively). The influence of placebo was 6%. The hypothesis is raised that the mechanism of action of clomiphene citrate is the correction of the hormonal disturbances in the luteal phase of the cycle following insertion of the IUD.The influence of clomiphene citrate was tested in 206 women suffering from menorrhagia following IUD insertion. 83% felt relief during the therapy, 10% did not benefit, and 7% complained of a worsening of their symptoms. Among the women who felt improvement, 85% responded to the 250 mg/cycle dosage and 15% required the 350 mg/cycle dosage. Women with shortened menstrual cycles required higher dosage as compared to those women with normal cycles (36% vs 28%). The influence of the placebo was 6%. The hypothesis is raised that the mechanism of action of clomiphene citrate is the correction of the hormonal disturbances in the luteal phase of the cycle following IUD insertion." @default.
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- W2050945462 date "1982-12-01" @default.
- W2050945462 modified "2023-09-27" @default.
- W2050945462 title "Menorrhagia associated with the wearing of IUD — the results of treatment with clomiphene citrate" @default.
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- W2050945462 doi "https://doi.org/10.1016/0028-2243(82)90094-6" @default.
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