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• W2050950912 abstract "We have constructed a model (Fig. 2) to explain the activation and regulation of autoreactive T cells by antigen. Antigen priming appears to be important for both antigen-specific and autoreactive T cells. Once activated, these T cells have the capacity to stimulate B cells to produce antibody in a very similar manner. It is possible that these two types of T cells work in concert to maintain an active immune response. Under circumstances where antigen-specific T-cell help may be limiting, autoreactive T cells may function to enhance B-cell responses. In addition, antigen appears to activate the regulatory mechanisms that are important for down-regulating the B-cell antibody response. Carrier-specific T-suppressor cells are antigen-specific in their activation but can be antigen-nonspecific in their effector function. In this way the regulatory mechanism driven by antigen can function to inactivate the antigen-specific and the autoreactive T-cell activation of B cells." @default.
• W2050950912 created "2016-06-24" @default.
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• W2050950912 date "1990-08-01" @default.
• W2050950912 modified "2023-10-01" @default.
• W2050950912 title "Function of Autoreactive T Cells in Immune Responses" @default.
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• W2050950912 doi "https://doi.org/10.1111/j.1600-065x.1990.tb00802.x" @default.
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