FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050954355> ?p ?o ?g. }

• W2050954355 endingPage "298" @default.
• W2050954355 startingPage "294" @default.
• W2050954355 abstract "We studied the effect of several doses of atropine on the serum gastrin and pancreatic polypeptide responses to vagal stimulation in healthy human subjects. Vagal stimulation was induced by sham feeding. To eliminate the effect of gastric acidity on gastrin release, gastric pH was held constant (pH 5) and acid secretion was measured by intragastric titration. Although a small dose of atropine (2.3 mug/kg) significantly inhibited the acid secretory response and completely abolished the pancreatic polypeptide response to sham feeding, this dose of atropine significantly enhanced the gastrin response. Higher atropine doses (7.0 and 21.0 mug/kg) had effects on gastrin and pancreatic polypeptide release which were similar to the 2.3-mug/kg dose. Atropine (0.78 and 2.3 mug/kg) without sham feeding significantly inhibited basal acid secretion and also led to significant increases in serum gastrin above basal levels. The gastrin response to sham feeding with 2.3 mug/kg atropine was significantly greater than the sum of the gastrin responses to sham feeding alone and to 2.3 mug/kg atropine alone, indicating potentiation of vagal gastrin release by atropine. We conclude: (a) Unlike vagally mediated gastric acid secretion and pancreatic polypeptide release which can be blocked by atropine, vagal gastrin release is potentiated by atropine. This observation suggests the existence of a vagal-cholinergic pathway which normally (i.e., in the absence of atropine) inhibits gastrin release. (b) Because atropine (without sham feeding) increased basal gastrin levels, it is likely that the cholinergic pathway which inhibits gastrin release is active even when the vagus nerve is not stimulated by sham feeding." @default.
• W2050954355 created "2016-06-24" @default.
• W2050954355 creator A5016664830 @default.
• W2050954355 creator A5020460397 @default.
• W2050954355 creator A5087460616 @default.
• W2050954355 creator A5091680206 @default.
• W2050954355 date "1979-02-01" @default.
• W2050954355 modified "2023-10-15" @default.
• W2050954355 title "Effect of Atropine on Vagal Release of Gastrin and Pancreatic Polypeptide" @default.
• W2050954355 cites W1421378609 @default.
• W2050954355 cites W1533322788 @default.
• W2050954355 cites W1581039174 @default.
• W2050954355 cites W1754487070 @default.
• W2050954355 cites W186887653 @default.
• W2050954355 cites W1876643048 @default.
• W2050954355 cites W1975973380 @default.
• W2050954355 cites W2007856514 @default.
• W2050954355 cites W2033785962 @default.
• W2050954355 cites W2035387800 @default.
• W2050954355 cites W2055992233 @default.
• W2050954355 cites W2084530950 @default.
• W2050954355 cites W2112054804 @default.
• W2050954355 cites W2117210104 @default.
• W2050954355 cites W2121715727 @default.
• W2050954355 cites W2148175977 @default.
• W2050954355 cites W2168924131 @default.
• W2050954355 cites W2398614918 @default.
• W2050954355 cites W2407178386 @default.
• W2050954355 cites W2413451347 @default.
• W2050954355 cites W2414642310 @default.
• W2050954355 cites W2417180106 @default.
• W2050954355 cites W2765711959 @default.
• W2050954355 doi "https://doi.org/10.1172/jci109302" @default.
• W2050954355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371952" @default.
• W2050954355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/429555" @default.
• W2050954355 hasPublicationYear "1979" @default.
• W2050954355 type Work @default.
• W2050954355 sameAs 2050954355 @default.
• W2050954355 citedByCount "129" @default.
• W2050954355 countsByYear W20509543552012 @default.
• W2050954355 countsByYear W20509543552015 @default.
• W2050954355 countsByYear W20509543552019 @default.
• W2050954355 countsByYear W20509543552020 @default.
• W2050954355 countsByYear W20509543552021 @default.
• W2050954355 crossrefType "journal-article" @default.
• W2050954355 hasAuthorship W2050954355A5016664830 @default.
• W2050954355 hasAuthorship W2050954355A5020460397 @default.
• W2050954355 hasAuthorship W2050954355A5087460616 @default.
• W2050954355 hasAuthorship W2050954355A5091680206 @default.
• W2050954355 hasBestOaLocation W20509543551 @default.
• W2050954355 hasConcept C119811328 @default.
• W2050954355 hasConcept C126322002 @default.
• W2050954355 hasConcept C134018914 @default.
• W2050954355 hasConcept C185592680 @default.
• W2050954355 hasConcept C22885893 @default.
• W2050954355 hasConcept C24998067 @default.
• W2050954355 hasConcept C2775859210 @default.
• W2050954355 hasConcept C2775910092 @default.
• W2050954355 hasConcept C2776986829 @default.
• W2050954355 hasConcept C2777504413 @default.
• W2050954355 hasConcept C2778024521 @default.
• W2050954355 hasConcept C2778108375 @default.
• W2050954355 hasConcept C2778395965 @default.
• W2050954355 hasConcept C2778563252 @default.
• W2050954355 hasConcept C2779306644 @default.
• W2050954355 hasConcept C49039625 @default.
• W2050954355 hasConcept C71315377 @default.
• W2050954355 hasConcept C71924100 @default.
• W2050954355 hasConceptScore W2050954355C119811328 @default.
• W2050954355 hasConceptScore W2050954355C126322002 @default.
• W2050954355 hasConceptScore W2050954355C134018914 @default.
• W2050954355 hasConceptScore W2050954355C185592680 @default.
• W2050954355 hasConceptScore W2050954355C22885893 @default.
• W2050954355 hasConceptScore W2050954355C24998067 @default.
• W2050954355 hasConceptScore W2050954355C2775859210 @default.
• W2050954355 hasConceptScore W2050954355C2775910092 @default.
• W2050954355 hasConceptScore W2050954355C2776986829 @default.
• W2050954355 hasConceptScore W2050954355C2777504413 @default.
• W2050954355 hasConceptScore W2050954355C2778024521 @default.
• W2050954355 hasConceptScore W2050954355C2778108375 @default.
• W2050954355 hasConceptScore W2050954355C2778395965 @default.
• W2050954355 hasConceptScore W2050954355C2778563252 @default.
• W2050954355 hasConceptScore W2050954355C2779306644 @default.
• W2050954355 hasConceptScore W2050954355C49039625 @default.
• W2050954355 hasConceptScore W2050954355C71315377 @default.
• W2050954355 hasConceptScore W2050954355C71924100 @default.
• W2050954355 hasIssue "2" @default.
• W2050954355 hasLocation W20509543551 @default.
• W2050954355 hasLocation W20509543552 @default.
• W2050954355 hasLocation W20509543553 @default.
• W2050954355 hasLocation W20509543554 @default.
• W2050954355 hasOpenAccess W2050954355 @default.
• W2050954355 hasPrimaryLocation W20509543551 @default.
• W2050954355 hasRelatedWork W1966913887 @default.
• W2050954355 hasRelatedWork W1999609659 @default.
• W2050954355 hasRelatedWork W2025635906 @default.
• W2050954355 hasRelatedWork W2026396774 @default.
• W2050954355 hasRelatedWork W2044589560 @default.

• next