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- W2050972088 abstract "Five human-human hybridoma cell lines secreting monoclonal antibodies (mAbs) against lipid A (LA) were produced by cell fusion of Epstein-Barr virus (EBV) transformed human peripheral blood lymphocytes and a human lymphoblastoid cell line KR-4. All these mAbs were isotyped as IgM(kappa) and reacted with lipopolysaccharides (LPS) and LA of various gram-negative bacteria. Whereas the binding of only four of the five mAbs to solid-phase LA was blocked by polymyxin-B sulphate, the mitogenic effect of LPS and LA on murine B lymphocytes was inhibited by all five mAbs. These results demonstrate that the human immune system recognizes at least two common epitopes in lipid A of various gram-negative bacteria." @default.
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- W2050972088 date "1988-06-01" @default.
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- W2050972088 title "Human — human hybridomas secreting lipid A reactive monoclonal antibodies" @default.
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- W2050972088 doi "https://doi.org/10.1016/0165-2478(88)90047-8" @default.
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