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- W2050972261 abstract "There is a worldwide epidemic of obesity and type 2 diabetes, two major public health concerns associated with alterations in both insulin and glucose signaling pathways. Glucose is not only an energy source but also controls the expression of key genes involved in energetic metabolism, through the glucose-signaling transcription factor, Carbohydrate Responsive Element Binding Protein (ChREBP). ChREBP has emerged as a central regulator of de novo fatty acid synthesis (lipogenesis) in response to glucose under both physiological and physiopathological conditions. Glucose activates ChREBP by regulating its entry from the cytosol to the nucleus, thereby promoting its binding to carbohydrate responsive element (ChoRE) in the promoter regions of glycolytic (L-PK) and lipogenic genes (ACC and FAS). We have previously reported that the inhibition of ChREBP in liver of obese ob/ob mice improves the metabolic alterations linked to obesity, fatty liver and insulin-resistance. Therefore, regulating ChREBP activity could be an attractive target for lipid-lowering therapies in obesity and diabetes. However, before this is possible, a better understanding of the mechanism(s) regulating its activity is needed. In this review, we summarize recent findings on the role and regulation of ChREBP and particularly emphasize on the cross-regulations that may exist between key nuclear receptors (LXR, TR, HNF4α) and ChREBP for the control of hepatic glucose metabolism. These novel molecular cross-talks may open the way to new pharmacological opportunities. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease." @default.
- W2050972261 created "2016-06-24" @default.
- W2050972261 creator A5039122462 @default.
- W2050972261 creator A5054233319 @default.
- W2050972261 date "2011-08-01" @default.
- W2050972261 modified "2023-10-16" @default.
- W2050972261 title "Cross-regulation of hepatic glucose metabolism via ChREBP and nuclear receptors" @default.
- W2050972261 cites W10748249 @default.
- W2050972261 cites W1488738929 @default.
- W2050972261 cites W1494992303 @default.
- W2050972261 cites W1509867470 @default.
- W2050972261 cites W1519104903 @default.
- W2050972261 cites W1570388980 @default.
- W2050972261 cites W1570718731 @default.
- W2050972261 cites W1576971163 @default.
- W2050972261 cites W1598615410 @default.
- W2050972261 cites W1748636648 @default.
- W2050972261 cites W1871599565 @default.
- W2050972261 cites W1968403297 @default.
- W2050972261 cites W1971412377 @default.
- W2050972261 cites W1973243569 @default.
- W2050972261 cites W1974186154 @default.
- W2050972261 cites W1974628563 @default.
- W2050972261 cites W1975070287 @default.
- W2050972261 cites W1979023718 @default.
- W2050972261 cites W1979144895 @default.
- W2050972261 cites W1982378715 @default.
- W2050972261 cites W1985592156 @default.
- W2050972261 cites W1988348937 @default.
- W2050972261 cites W1988405792 @default.
- W2050972261 cites W1990675136 @default.
- W2050972261 cites W1991480596 @default.
- W2050972261 cites W1993700780 @default.
- W2050972261 cites W1996168740 @default.
- W2050972261 cites W2000045912 @default.
- W2050972261 cites W2000154217 @default.
- W2050972261 cites W2000973674 @default.
- W2050972261 cites W2002702358 @default.
- W2050972261 cites W2003260371 @default.
- W2050972261 cites W2005602228 @default.
- W2050972261 cites W2006574739 @default.
- W2050972261 cites W2009098630 @default.
- W2050972261 cites W2009577529 @default.
- W2050972261 cites W2009624930 @default.
- W2050972261 cites W2011205686 @default.
- W2050972261 cites W2012443360 @default.
- W2050972261 cites W2015711200 @default.
- W2050972261 cites W2016049443 @default.
- W2050972261 cites W2016211755 @default.
- W2050972261 cites W2016676112 @default.
- W2050972261 cites W2018336213 @default.
- W2050972261 cites W2018504516 @default.
- W2050972261 cites W2024851295 @default.
- W2050972261 cites W2026555269 @default.
- W2050972261 cites W2027273404 @default.
- W2050972261 cites W2028102364 @default.
- W2050972261 cites W2031030976 @default.
- W2050972261 cites W2031284769 @default.
- W2050972261 cites W2033190611 @default.
- W2050972261 cites W2033396645 @default.
- W2050972261 cites W2034790783 @default.
- W2050972261 cites W2035225324 @default.
- W2050972261 cites W2035733956 @default.
- W2050972261 cites W2035837644 @default.
- W2050972261 cites W2037667733 @default.
- W2050972261 cites W2038126428 @default.
- W2050972261 cites W2039307052 @default.
- W2050972261 cites W2039532381 @default.
- W2050972261 cites W2039928578 @default.
- W2050972261 cites W2040417680 @default.
- W2050972261 cites W2044237765 @default.
- W2050972261 cites W2048346753 @default.
- W2050972261 cites W2050207944 @default.
- W2050972261 cites W2050899411 @default.
- W2050972261 cites W2054799199 @default.
- W2050972261 cites W2056113150 @default.
- W2050972261 cites W2056378761 @default.
- W2050972261 cites W2057162495 @default.
- W2050972261 cites W2057343748 @default.
- W2050972261 cites W2058784350 @default.
- W2050972261 cites W2060044894 @default.
- W2050972261 cites W2060405598 @default.
- W2050972261 cites W2061864595 @default.
- W2050972261 cites W2062171482 @default.
- W2050972261 cites W2062470598 @default.
- W2050972261 cites W2063398921 @default.
- W2050972261 cites W2063595078 @default.
- W2050972261 cites W2066728242 @default.
- W2050972261 cites W2067729127 @default.
- W2050972261 cites W2068124794 @default.
- W2050972261 cites W2068458442 @default.
- W2050972261 cites W2073625229 @default.
- W2050972261 cites W2074889340 @default.
- W2050972261 cites W2074970072 @default.
- W2050972261 cites W2083819344 @default.
- W2050972261 cites W2086907474 @default.
- W2050972261 cites W2090024435 @default.
- W2050972261 cites W2091277139 @default.