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• W2050974771 abstract "Adherence of human lymphocytes to allogeneic tumour cell monolayers was found to depend on the presence of monocytes. Adherent lymphocytes could lie separated from tumour cells by treatment with lidocaine followed by nylon wool passage. Tumour-adherent cells (70% E-RFC, 45% Fcγ-R, 23% Fcμ-R, 5% monocytes) exhibited enriched natural killer (NK) activity not only against the tumour cell line used for isolation but also against seven other targets. When T cells were isolated subsequently as E-rosettes by density gradient centrifugation through Percoll, the enrichment in cytotoxicity was even more pronounced. Tumour-adherent T cells were severalfold enriched in both N K and antibody-dependent cell-mediated cytotoxicity (ADCC) activity. However, this enrichment was not paralleled by a concomitant increase in the number of Tγ cells (tumour-adherent T cells: 17% Tγ, 40% Tμ: tumour-nonadherent T cells: 12% Tγ, 60% Tμ). Marked differences could be observed by staining with a monoclonal antibody that was raised against human leukaemic Tγ cells of high NK and ADCC activity. This antibody (T8–11) stained 60% of tumour-adherent T cells. 20% of nonadherent T cells and 29% of T-cell controls. These results indicate that the spontaneous cyloloxic activity of human T cells resides within a small population, most of which are characterized by a specific surface antigen but not by conventional Fcγ receptors." @default.
• W2050974771 created "2016-06-24" @default.
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• W2050974771 date "1982-05-01" @default.
• W2050974771 modified "2023-10-17" @default.
• W2050974771 title "Natural and Antibody-Dependent Cellular Cytotoxicity in Tumour-Adherent T Lymphocytes: Expression of Fc Receptors and of a Human T-Subgroup-Specific Antigen" @default.
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• W2050974771 doi "https://doi.org/10.1111/j.1365-3083.1982.tb00674.x" @default.
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