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• W2050974910 abstract "The actions of melatonin on high-voltage activated calcium channels (HVACC) and intracellular free Ca2+ concentration in cultured dorsal root ganglion (DRG) neurones from neonatal rats were investigated using the whole-cell patch clamp and the fura-2 fluorescence ratio Ca2+-imaging techniques. HVACC were pharmacologically and biophysically isolated and the effects of melatonin were investigated. Extracellular application of melatonin inhibited HVACC in a dose dependent manner. In calcium imaging experiments, application of extracellular recording medium containing 30 mM KCl evoked increases in intracellular free Ca2+ that were dependent upon external Ca2+ ions. This increase was prevented by both low (10 μM) and high dose (100 μM) of melatonin pre-treatment. The results of this study indicate that the pineal hormone melatonin has inhibitory actions on voltage dependent calcium entry in cultured rat DRG neurones." @default.
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• W2050974910 date "2001-11-01" @default.
• W2050974910 modified "2023-10-13" @default.
• W2050974910 title "Melatonin inhibits high voltage activated calcium currents in cultured rat dorsal root ganglion neurones" @default.
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• W2050974910 doi "https://doi.org/10.1016/s0304-3940(01)02188-7" @default.
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