FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050975036> ?p ?o ?g. }

• W2050975036 endingPage "376" @default.
• W2050975036 startingPage "367" @default.
• W2050975036 abstract "Peroxisome proliferator activated receptors (PPARs, alpha, beta/delta, gamma) control lipid homeostasis and differentiation in various tissues and tumor cells. PPARbeta and PPARgamma increase oligodendrocyte maturation in glial mixed populations and spinal cord oligodendrocytes, respectively, and PPARbeta is known to modulate the activity of other PPARs. To assess a possible interaction between PPARs in glial cell differentiation we used the undifferentiated C6 glioma cell line as model. These cells express all three PPARs, but only PPARgamma shows transcriptional activity in agonist-based reporter gene assay. Agonist-activated PPARgamma up-regulates oligodendrocyte markers, down-regulates an astrocyte marker, and increases alkyl-dihydroxyacetone phosphate synthase, enzyme involved in the synthesis of myelin-rich plasmalogens. Similar effects are induced in PPARgamma overexpressing cells, which in addition show PPARbeta up-regulation. PPARbeta or PPARalpha agonists show no effect. Nevertheless, PPARbeta overexpression up-regulates PPARgamma and commits C6 cells to oligodendrocytes; effect that is abrogated by a PPARgamma antagonist or PPARgamma interference RNA. Moreover, PPARbeta overexpression also induces PPARalpha and its target genes, including acyl-CoA oxidase, enzyme involved in very long chain fatty acid recycling, and in the synthesis of myelin components such as docosahexaenoic acid. These results indicate for the first time, that PPARs concertedly cooperate in C6 glioma cell differentiation to oligodendrocytes. Further, they suggest that active PPARbeta might be essential for increasing oligodendrocyte distinctive markers and enzymes required for myelin synthesis in C6 glioma cells through up-regulation of PPARgamma and PPARalpha." @default.
• W2050975036 created "2016-06-24" @default.
• W2050975036 creator A5007568174 @default.
• W2050975036 creator A5025540981 @default.
• W2050975036 creator A5032699103 @default.
• W2050975036 creator A5067990017 @default.
• W2050975036 creator A5090029281 @default.
• W2050975036 date "2008-11-01" @default.
• W2050975036 modified "2023-09-27" @default.
• W2050975036 title "A PPARs cross-talk concertedly commits C6 glioma cells to oligodendrocytes and induces enzymes involved in myelin synthesis" @default.
• W2050975036 cites W1536266814 @default.
• W2050975036 cites W1547032503 @default.
• W2050975036 cites W1582985794 @default.
• W2050975036 cites W1602972089 @default.
• W2050975036 cites W1982971009 @default.
• W2050975036 cites W1984426938 @default.
• W2050975036 cites W1986712005 @default.
• W2050975036 cites W1994871837 @default.
• W2050975036 cites W1995813003 @default.
• W2050975036 cites W1996267589 @default.
• W2050975036 cites W1998788702 @default.
• W2050975036 cites W2003644239 @default.
• W2050975036 cites W2003720806 @default.
• W2050975036 cites W2016443141 @default.
• W2050975036 cites W2031919883 @default.
• W2050975036 cites W2032754533 @default.
• W2050975036 cites W2034089831 @default.
• W2050975036 cites W2036997117 @default.
• W2050975036 cites W2037971926 @default.
• W2050975036 cites W2047982128 @default.
• W2050975036 cites W2054520162 @default.
• W2050975036 cites W2060295481 @default.
• W2050975036 cites W2061262646 @default.
• W2050975036 cites W2064715676 @default.
• W2050975036 cites W2065485581 @default.
• W2050975036 cites W2066585902 @default.
• W2050975036 cites W2069406319 @default.
• W2050975036 cites W2076455660 @default.
• W2050975036 cites W2091673549 @default.
• W2050975036 cites W2111966501 @default.
• W2050975036 cites W2119068792 @default.
• W2050975036 cites W2121223003 @default.
• W2050975036 cites W2121914083 @default.
• W2050975036 cites W2131471654 @default.
• W2050975036 cites W2148403865 @default.
• W2050975036 cites W2156390974 @default.
• W2050975036 cites W2162178319 @default.
• W2050975036 cites W2170169143 @default.
• W2050975036 cites W2187954739 @default.
• W2050975036 cites W4248955105 @default.
• W2050975036 doi "https://doi.org/10.1002/jcp.21509" @default.
• W2050975036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18543250" @default.
• W2050975036 hasPublicationYear "2008" @default.
• W2050975036 type Work @default.
• W2050975036 sameAs 2050975036 @default.
• W2050975036 citedByCount "25" @default.
• W2050975036 countsByYear W20509750362012 @default.
• W2050975036 countsByYear W20509750362013 @default.
• W2050975036 countsByYear W20509750362014 @default.
• W2050975036 countsByYear W20509750362015 @default.
• W2050975036 countsByYear W20509750362016 @default.
• W2050975036 countsByYear W20509750362017 @default.
• W2050975036 countsByYear W20509750362018 @default.
• W2050975036 countsByYear W20509750362020 @default.
• W2050975036 countsByYear W20509750362021 @default.
• W2050975036 countsByYear W20509750362022 @default.
• W2050975036 crossrefType "journal-article" @default.
• W2050975036 hasAuthorship W2050975036A5007568174 @default.
• W2050975036 hasAuthorship W2050975036A5025540981 @default.
• W2050975036 hasAuthorship W2050975036A5032699103 @default.
• W2050975036 hasAuthorship W2050975036A5067990017 @default.
• W2050975036 hasAuthorship W2050975036A5090029281 @default.
• W2050975036 hasConcept C104317684 @default.
• W2050975036 hasConcept C134018914 @default.
• W2050975036 hasConcept C148738053 @default.
• W2050975036 hasConcept C170493617 @default.
• W2050975036 hasConcept C185592680 @default.
• W2050975036 hasConcept C187345961 @default.
• W2050975036 hasConcept C2776985911 @default.
• W2050975036 hasConcept C2777542381 @default.
• W2050975036 hasConcept C2778486448 @default.
• W2050975036 hasConcept C2778609137 @default.
• W2050975036 hasConcept C2780884517 @default.
• W2050975036 hasConcept C2781017270 @default.
• W2050975036 hasConcept C529278444 @default.
• W2050975036 hasConcept C55493867 @default.
• W2050975036 hasConcept C63932345 @default.
• W2050975036 hasConcept C86339819 @default.
• W2050975036 hasConcept C86803240 @default.
• W2050975036 hasConcept C95444343 @default.
• W2050975036 hasConceptScore W2050975036C104317684 @default.
• W2050975036 hasConceptScore W2050975036C134018914 @default.
• W2050975036 hasConceptScore W2050975036C148738053 @default.
• W2050975036 hasConceptScore W2050975036C170493617 @default.
• W2050975036 hasConceptScore W2050975036C185592680 @default.
• W2050975036 hasConceptScore W2050975036C187345961 @default.
• W2050975036 hasConceptScore W2050975036C2776985911 @default.
• W2050975036 hasConceptScore W2050975036C2777542381 @default.

• next