FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050992006> ?p ?o ?g. }

• W2050992006 endingPage "68" @default.
• W2050992006 startingPage "59" @default.
• W2050992006 abstract "The mechanisms by which Ca(2+)-independent phospholipase A(2) (iPLA(2)) mediates cell growth in p53-positive LNCaP and p53-negative PC-3 prostate cancer cell lines were studied. Exposure of cells to the iPLA(2) selective inhibitor bromoenol lactone (BEL; 0-20 microM) induced concentration- and time-dependent decreases in cell growth based on 3-(4, dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide staining and cell number. Decreased cell growth was not caused by cell death as BEL exposure did not alter nuclear morphology or increase annexin V (apoptotic cell marker) or propidium iodide (necrotic cell marker) staining after 48 h. Decreased growth correlated to a G(1)/G(0) arrest in LNCaP cells and aG(2)/M arrest in PC-3 cells. In LNCaP cells, G(1) arrest was preceded by time- (0-48 h) and concentration-dependent (0-10 microM) increases in the expression of the tumor suppressor protein p53 and the cyclin-dependent kinase inhibitor p21. Increases in p53 expression preceded increases in p21 expression by 8 h. In LNCaP cells, BEL treatment decreased the expression of the p53 antagonist Mdm2, while increasing Akt phosphorylation. BEL treatment also increased Akt phosphorylation in PC-3 cells, but Mdm2 was not detected. The ability of BEL to increase Akt phosphorylation was inhibited by the phosphoinositide 3-kinase inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]. BEL treatment also decreased agonist-induced activation of the epidermal growth factor receptor. These data suggest that inhibition of iPLA(2) decreases prostate cancer cell growth by p53-dependent and independent mechanisms. Furthermore, alterations in Mdm2 and epidermal growth factor receptor activation following BEL exposure suggest novel roles for iPLA(2) in prostate cancer cell signaling." @default.
• W2050992006 created "2016-06-24" @default.
• W2050992006 creator A5006007746 @default.
• W2050992006 creator A5029934159 @default.
• W2050992006 creator A5033980467 @default.
• W2050992006 creator A5088751741 @default.
• W2050992006 date "2008-04-25" @default.
• W2050992006 modified "2023-10-16" @default.
• W2050992006 title "Inhibition of Ca²⁺-Independent Phospholipase A₂ Decreases Prostate Cancer Cell Growth by p53-Dependent and Independent Mechanisms" @default.
• W2050992006 cites W1964722330 @default.
• W2050992006 cites W1976282831 @default.
• W2050992006 cites W1979433385 @default.
• W2050992006 cites W1980266047 @default.
• W2050992006 cites W1983751803 @default.
• W2050992006 cites W1989306272 @default.
• W2050992006 cites W1999266701 @default.
• W2050992006 cites W2004542452 @default.
• W2050992006 cites W2011102246 @default.
• W2050992006 cites W2014939913 @default.
• W2050992006 cites W2015483949 @default.
• W2050992006 cites W2015915313 @default.
• W2050992006 cites W2018539716 @default.
• W2050992006 cites W2019666648 @default.
• W2050992006 cites W2025143628 @default.
• W2050992006 cites W2026609154 @default.
• W2050992006 cites W2027188394 @default.
• W2050992006 cites W2027217537 @default.
• W2050992006 cites W2027321140 @default.
• W2050992006 cites W2027431992 @default.
• W2050992006 cites W2032867124 @default.
• W2050992006 cites W2038305733 @default.
• W2050992006 cites W2042217228 @default.
• W2050992006 cites W2048876993 @default.
• W2050992006 cites W2050308393 @default.
• W2050992006 cites W2062203427 @default.
• W2050992006 cites W2065752512 @default.
• W2050992006 cites W2073292665 @default.
• W2050992006 cites W2082276468 @default.
• W2050992006 cites W2085475071 @default.
• W2050992006 cites W2085679570 @default.
• W2050992006 cites W2087576138 @default.
• W2050992006 cites W2103379588 @default.
• W2050992006 cites W2133555758 @default.
• W2050992006 cites W2137276161 @default.
• W2050992006 cites W2141355544 @default.
• W2050992006 cites W2163076966 @default.
• W2050992006 cites W2168947315 @default.
• W2050992006 cites W23620893 @default.
• W2050992006 cites W4205765598 @default.
• W2050992006 doi "https://doi.org/10.1124/jpet.108.138958" @default.
• W2050992006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18441250" @default.
• W2050992006 hasPublicationYear "2008" @default.
• W2050992006 type Work @default.
• W2050992006 sameAs 2050992006 @default.
• W2050992006 citedByCount "27" @default.
• W2050992006 countsByYear W20509920062012 @default.
• W2050992006 countsByYear W20509920062013 @default.
• W2050992006 countsByYear W20509920062015 @default.
• W2050992006 countsByYear W20509920062018 @default.
• W2050992006 countsByYear W20509920062021 @default.
• W2050992006 countsByYear W20509920062023 @default.
• W2050992006 crossrefType "journal-article" @default.
• W2050992006 hasAuthorship W2050992006A5006007746 @default.
• W2050992006 hasAuthorship W2050992006A5029934159 @default.
• W2050992006 hasAuthorship W2050992006A5033980467 @default.
• W2050992006 hasAuthorship W2050992006A5088751741 @default.
• W2050992006 hasConcept C121608353 @default.
• W2050992006 hasConcept C126322002 @default.
• W2050992006 hasConcept C134018914 @default.
• W2050992006 hasConcept C153911025 @default.
• W2050992006 hasConcept C190283241 @default.
• W2050992006 hasConcept C2775934118 @default.
• W2050992006 hasConcept C2776062698 @default.
• W2050992006 hasConcept C2779707156 @default.
• W2050992006 hasConcept C2779723316 @default.
• W2050992006 hasConcept C29537977 @default.
• W2050992006 hasConcept C31573885 @default.
• W2050992006 hasConcept C502942594 @default.
• W2050992006 hasConcept C54355233 @default.
• W2050992006 hasConcept C55493867 @default.
• W2050992006 hasConcept C62112901 @default.
• W2050992006 hasConcept C71924100 @default.
• W2050992006 hasConcept C75217442 @default.
• W2050992006 hasConcept C86803240 @default.
• W2050992006 hasConcept C88634738 @default.
• W2050992006 hasConcept C96232424 @default.
• W2050992006 hasConceptScore W2050992006C121608353 @default.
• W2050992006 hasConceptScore W2050992006C126322002 @default.
• W2050992006 hasConceptScore W2050992006C134018914 @default.
• W2050992006 hasConceptScore W2050992006C153911025 @default.
• W2050992006 hasConceptScore W2050992006C190283241 @default.
• W2050992006 hasConceptScore W2050992006C2775934118 @default.
• W2050992006 hasConceptScore W2050992006C2776062698 @default.
• W2050992006 hasConceptScore W2050992006C2779707156 @default.
• W2050992006 hasConceptScore W2050992006C2779723316 @default.
• W2050992006 hasConceptScore W2050992006C29537977 @default.
• W2050992006 hasConceptScore W2050992006C31573885 @default.
• W2050992006 hasConceptScore W2050992006C502942594 @default.

• next