Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050996818> ?p ?o ?g. }
- W2050996818 endingPage "e80223" @default.
- W2050996818 startingPage "e80223" @default.
- W2050996818 abstract "Apoptosis and necrosis, two major forms of cell death, can be distinguished morphologically and biochemically. Internucleosomal DNA fragmentation (INDF) is a biochemical hallmark of apoptosis, and caspase-activated DNase (CAD), also known as DNA fragmentation factor 40 kDa (DFF40), is one of the major effector endonucleases. DNase γ, a Mg2+/Ca2+-dependent endonuclease, is also known to generate INDF but its role among other apoptosis-associated endonucleases in cell death is unclear. Here we show that (i) INDF occurs even during necrosis in cell lines, primary cells, and in tissues of mice in vivo, and (ii) DNase γ, but not CAD, is the effector endonuclease for INDF in cells undergoing necrosis. These results document a previously unappreciated role for INDF in necrosis and define its molecular basis." @default.
- W2050996818 created "2016-06-24" @default.
- W2050996818 creator A5002128951 @default.
- W2050996818 creator A5005186079 @default.
- W2050996818 creator A5005802953 @default.
- W2050996818 creator A5011658917 @default.
- W2050996818 creator A5018894353 @default.
- W2050996818 creator A5021338138 @default.
- W2050996818 creator A5030252459 @default.
- W2050996818 creator A5067050093 @default.
- W2050996818 creator A5086186800 @default.
- W2050996818 date "2013-12-02" @default.
- W2050996818 modified "2023-10-02" @default.
- W2050996818 title "DNase γ Is the Effector Endonuclease for Internucleosomal DNA Fragmentation in Necrosis" @default.
- W2050996818 cites W1480948328 @default.
- W2050996818 cites W1492302205 @default.
- W2050996818 cites W1567114372 @default.
- W2050996818 cites W161444417 @default.
- W2050996818 cites W1857778690 @default.
- W2050996818 cites W1933915416 @default.
- W2050996818 cites W1967550651 @default.
- W2050996818 cites W1968350013 @default.
- W2050996818 cites W1980792888 @default.
- W2050996818 cites W1993614010 @default.
- W2050996818 cites W2001082792 @default.
- W2050996818 cites W2007837805 @default.
- W2050996818 cites W2012948694 @default.
- W2050996818 cites W2032177235 @default.
- W2050996818 cites W2036194977 @default.
- W2050996818 cites W2040898123 @default.
- W2050996818 cites W2042556742 @default.
- W2050996818 cites W2047168565 @default.
- W2050996818 cites W2051181153 @default.
- W2050996818 cites W2052116757 @default.
- W2050996818 cites W2054460964 @default.
- W2050996818 cites W2082259697 @default.
- W2050996818 cites W2091058610 @default.
- W2050996818 cites W2095082862 @default.
- W2050996818 cites W2095334082 @default.
- W2050996818 cites W2110796758 @default.
- W2050996818 cites W2124806810 @default.
- W2050996818 cites W2125483893 @default.
- W2050996818 cites W2136346308 @default.
- W2050996818 cites W2158679391 @default.
- W2050996818 cites W2164412888 @default.
- W2050996818 cites W2170959088 @default.
- W2050996818 cites W2172176216 @default.
- W2050996818 cites W2278131836 @default.
- W2050996818 doi "https://doi.org/10.1371/journal.pone.0080223" @default.
- W2050996818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3846476" @default.
- W2050996818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24312463" @default.
- W2050996818 hasPublicationYear "2013" @default.
- W2050996818 type Work @default.
- W2050996818 sameAs 2050996818 @default.
- W2050996818 citedByCount "46" @default.
- W2050996818 countsByYear W20509968182014 @default.
- W2050996818 countsByYear W20509968182015 @default.
- W2050996818 countsByYear W20509968182016 @default.
- W2050996818 countsByYear W20509968182017 @default.
- W2050996818 countsByYear W20509968182018 @default.
- W2050996818 countsByYear W20509968182019 @default.
- W2050996818 countsByYear W20509968182020 @default.
- W2050996818 countsByYear W20509968182021 @default.
- W2050996818 countsByYear W20509968182022 @default.
- W2050996818 countsByYear W20509968182023 @default.
- W2050996818 crossrefType "journal-article" @default.
- W2050996818 hasAuthorship W2050996818A5002128951 @default.
- W2050996818 hasAuthorship W2050996818A5005186079 @default.
- W2050996818 hasAuthorship W2050996818A5005802953 @default.
- W2050996818 hasAuthorship W2050996818A5011658917 @default.
- W2050996818 hasAuthorship W2050996818A5018894353 @default.
- W2050996818 hasAuthorship W2050996818A5021338138 @default.
- W2050996818 hasAuthorship W2050996818A5030252459 @default.
- W2050996818 hasAuthorship W2050996818A5067050093 @default.
- W2050996818 hasAuthorship W2050996818A5086186800 @default.
- W2050996818 hasBestOaLocation W20509968181 @default.
- W2050996818 hasConcept C153911025 @default.
- W2050996818 hasConcept C18903297 @default.
- W2050996818 hasConcept C190283241 @default.
- W2050996818 hasConcept C191015642 @default.
- W2050996818 hasConcept C2777028655 @default.
- W2050996818 hasConcept C2779377703 @default.
- W2050996818 hasConcept C3017666073 @default.
- W2050996818 hasConcept C31573885 @default.
- W2050996818 hasConcept C43759708 @default.
- W2050996818 hasConcept C503630168 @default.
- W2050996818 hasConcept C51785407 @default.
- W2050996818 hasConcept C54355233 @default.
- W2050996818 hasConcept C552990157 @default.
- W2050996818 hasConcept C86803240 @default.
- W2050996818 hasConcept C87439868 @default.
- W2050996818 hasConcept C95444343 @default.
- W2050996818 hasConceptScore W2050996818C153911025 @default.
- W2050996818 hasConceptScore W2050996818C18903297 @default.
- W2050996818 hasConceptScore W2050996818C190283241 @default.
- W2050996818 hasConceptScore W2050996818C191015642 @default.
- W2050996818 hasConceptScore W2050996818C2777028655 @default.
- W2050996818 hasConceptScore W2050996818C2779377703 @default.