Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051003359> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2051003359 endingPage "360" @default.
- W2051003359 startingPage "355" @default.
- W2051003359 abstract "The relevance of the GABAergic system for the antihypertensive action of metoprolol in spontaneously hypertensive rats was studied by comparing the effect of metoprolol with the effect of dihydralazine. Chronic oral treatment with metoprolol produced the maximum effect after 49 days (-delta 34 mm Hg). This effect persisted on the same level for up to 55 days. The measurements of gamma-aminobutyric acid (GABA) synthesis and specific [3H]GABA binding were performed in the hypothalamus, the pons-medulla, the hippocampus and the striatum. Significant stimulation of GABA synthesis and turnover appeared in the hypothalamus and the pons medulla. In contrast, chronic administration of dihydralazine had no influence on GABA synthesis rate. It was also shown that metoprolol elevated significantly (P < 0.01) specific [3H]GABA binding in the hypothalamus and the pons-medulla. In the striatum this effect of metoprolol was less pronounced. Binding constant analysis revealed changes in both the receptor density and affinity. Our results suggest that the hypotensive response to chronic treatment with metoprolol might be attributed to an enhancement of GABAergic system activity." @default.
- W2051003359 created "2016-06-24" @default.
- W2051003359 creator A5015716334 @default.
- W2051003359 creator A5025145196 @default.
- W2051003359 creator A5055277361 @default.
- W2051003359 creator A5068151743 @default.
- W2051003359 date "1993-12-01" @default.
- W2051003359 modified "2023-10-18" @default.
- W2051003359 title "Enhancement of GABAergic system activity by metoprolol in spontaneously hypertensive rats" @default.
- W2051003359 cites W1755280605 @default.
- W2051003359 cites W1775749144 @default.
- W2051003359 cites W1966990346 @default.
- W2051003359 cites W1972594873 @default.
- W2051003359 cites W1984966396 @default.
- W2051003359 cites W1988483578 @default.
- W2051003359 cites W1988814670 @default.
- W2051003359 cites W1990880840 @default.
- W2051003359 cites W1992590030 @default.
- W2051003359 cites W1993089418 @default.
- W2051003359 cites W1998806385 @default.
- W2051003359 cites W2004376628 @default.
- W2051003359 cites W2009696317 @default.
- W2051003359 cites W2013265069 @default.
- W2051003359 cites W2015311194 @default.
- W2051003359 cites W2018671604 @default.
- W2051003359 cites W2029562834 @default.
- W2051003359 cites W2029569556 @default.
- W2051003359 cites W2047861063 @default.
- W2051003359 cites W2049927314 @default.
- W2051003359 cites W2053937323 @default.
- W2051003359 cites W2064298592 @default.
- W2051003359 cites W2075833924 @default.
- W2051003359 cites W2082176927 @default.
- W2051003359 cites W2083690031 @default.
- W2051003359 cites W2088311563 @default.
- W2051003359 cites W2419451105 @default.
- W2051003359 doi "https://doi.org/10.1016/0014-2999(93)90021-9" @default.
- W2051003359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8112395" @default.
- W2051003359 hasPublicationYear "1993" @default.
- W2051003359 type Work @default.
- W2051003359 sameAs 2051003359 @default.
- W2051003359 citedByCount "2" @default.
- W2051003359 crossrefType "journal-article" @default.
- W2051003359 hasAuthorship W2051003359A5015716334 @default.
- W2051003359 hasAuthorship W2051003359A5025145196 @default.
- W2051003359 hasAuthorship W2051003359A5055277361 @default.
- W2051003359 hasAuthorship W2051003359A5068151743 @default.
- W2051003359 hasConcept C126322002 @default.
- W2051003359 hasConcept C134018914 @default.
- W2051003359 hasConcept C170493617 @default.
- W2051003359 hasConcept C17291353 @default.
- W2051003359 hasConcept C185592680 @default.
- W2051003359 hasConcept C24998067 @default.
- W2051003359 hasConcept C2777003273 @default.
- W2051003359 hasConcept C2778897929 @default.
- W2051003359 hasConcept C2779177108 @default.
- W2051003359 hasConcept C2780062018 @default.
- W2051003359 hasConcept C2781280847 @default.
- W2051003359 hasConcept C513476851 @default.
- W2051003359 hasConcept C71924100 @default.
- W2051003359 hasConceptScore W2051003359C126322002 @default.
- W2051003359 hasConceptScore W2051003359C134018914 @default.
- W2051003359 hasConceptScore W2051003359C170493617 @default.
- W2051003359 hasConceptScore W2051003359C17291353 @default.
- W2051003359 hasConceptScore W2051003359C185592680 @default.
- W2051003359 hasConceptScore W2051003359C24998067 @default.
- W2051003359 hasConceptScore W2051003359C2777003273 @default.
- W2051003359 hasConceptScore W2051003359C2778897929 @default.
- W2051003359 hasConceptScore W2051003359C2779177108 @default.
- W2051003359 hasConceptScore W2051003359C2780062018 @default.
- W2051003359 hasConceptScore W2051003359C2781280847 @default.
- W2051003359 hasConceptScore W2051003359C513476851 @default.
- W2051003359 hasConceptScore W2051003359C71924100 @default.
- W2051003359 hasIssue "3" @default.
- W2051003359 hasLocation W20510033591 @default.
- W2051003359 hasLocation W20510033592 @default.
- W2051003359 hasOpenAccess W2051003359 @default.
- W2051003359 hasPrimaryLocation W20510033591 @default.
- W2051003359 hasRelatedWork W2034583712 @default.
- W2051003359 hasRelatedWork W2034768996 @default.
- W2051003359 hasRelatedWork W2051488242 @default.
- W2051003359 hasRelatedWork W2054521012 @default.
- W2051003359 hasRelatedWork W2054992011 @default.
- W2051003359 hasRelatedWork W2064416809 @default.
- W2051003359 hasRelatedWork W2070793461 @default.
- W2051003359 hasRelatedWork W2414846389 @default.
- W2051003359 hasRelatedWork W2773858965 @default.
- W2051003359 hasRelatedWork W98806574 @default.
- W2051003359 hasVolume "250" @default.
- W2051003359 isParatext "false" @default.
- W2051003359 isRetracted "false" @default.
- W2051003359 magId "2051003359" @default.
- W2051003359 workType "article" @default.