FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051007170> ?p ?o ?g. }

• W2051007170 endingPage "517" @default.
• W2051007170 startingPage "503" @default.
• W2051007170 abstract "Major depression is a chronic psychiatric illness that is highly prevalent and disabling. The available medications are ineffective for many patients suggesting that differents molecular pathways could be specifically altered in the unresponsive patients. Recently, the glutamatergic system has emerged as a target in the research on depression and acute NMDA receptor blockade has been shown to produce strong antidepressant effects. We have studied the adaptations of four mice strains (C57BL/6, DBA/2, C3H and BALB/c) to a chronic unpredictable stress protocol, a widely used model of depression in rodents. BALB/c mice displayed strikingly different behavioral and neurochemical adaptations compared to the other strains tested, suggesting that different molecular pathways are involved in their specific vulnerability. They became hyperactive during the dark period, anhedonic-like and displayed no alterations in the tail suspension test (TST). After chronic stress, only the BALB/c displayed an increased frontocortical VGLUT1 expression which is suggestive of a dysregulation of their prefrontal glutamatergic system, and no BDNF mRNA alteration, although the acute stress modulation of this mRNA is similar to the other strains. Chronic administration of an antagonist of NMDA receptors, MK-801, induced antidepressant-like effects in the TST for stressed BALB/c, but was ineffective for the hyperactivity and anhedonia-like behavior, in contrast to fluoxetine. Chronic MK-801 was totally inactive on the behavior of stressed C57BL/6 mice. MK-801, but not fluoxetine, inhibited the VGLUT1 prefrontal increase in BALB/c. Fluoxetine increased VGLUT1 and BDNF mRNA expression in the hippocampus of the C57BL/6 but not in the BALB/c strain, suggesting a different reactivity in-between strain to both stress and antidepressant. Interestingly enough, the BDNF or VGLUT1 increase is not necessary to reverse the stress induced behavioral alterations in our experimental settings. This observation supports the conclusion that BDNF and VGLUT1 are depressive state markers, but not involved in its etiology. Finally, there is a substantial similarity between the phenotypes that are observed in the BALB/c mice and endogenous depression in humans, as well as between C57BL/6 mice and atypical depression. To have a better understanding of the variability of depression etiologies in human, and the implication of the glutamatergic system, it may be suggested that future animal studies in the mouse would systematically compare the two strains BALB/c and C57BL/6 for the identification of relevant biological mechanisms. This article is part of a special Issue entitled ‘Anxiety and Depression’." @default.
• W2051007170 created "2016-06-24" @default.
• W2051007170 creator A5006041048 @default.
• W2051007170 creator A5018244219 @default.
• W2051007170 creator A5019091466 @default.
• W2051007170 creator A5060897352 @default.
• W2051007170 date "2012-01-01" @default.
• W2051007170 modified "2023-10-08" @default.
• W2051007170 title "Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: Effects of fluoxetine and MK-801" @default.
• W2051007170 cites W1491963713 @default.
• W2051007170 cites W1523102865 @default.
• W2051007170 cites W1582986153 @default.
• W2051007170 cites W1630907922 @default.
• W2051007170 cites W166919779 @default.
• W2051007170 cites W1885584728 @default.
• W2051007170 cites W1914011667 @default.
• W2051007170 cites W1914381346 @default.
• W2051007170 cites W1950744654 @default.
• W2051007170 cites W1965259361 @default.
• W2051007170 cites W1968497578 @default.
• W2051007170 cites W1970627396 @default.
• W2051007170 cites W1972861207 @default.
• W2051007170 cites W1975208323 @default.
• W2051007170 cites W1975589456 @default.
• W2051007170 cites W1977118330 @default.
• W2051007170 cites W1979948882 @default.
• W2051007170 cites W1981102082 @default.
• W2051007170 cites W1989444437 @default.
• W2051007170 cites W1992668905 @default.
• W2051007170 cites W1993300625 @default.
• W2051007170 cites W1995556701 @default.
• W2051007170 cites W1999032208 @default.
• W2051007170 cites W2001817445 @default.
• W2051007170 cites W2003190343 @default.
• W2051007170 cites W2003983445 @default.
• W2051007170 cites W2005096312 @default.
• W2051007170 cites W2005594217 @default.
• W2051007170 cites W2011748173 @default.
• W2051007170 cites W2017242154 @default.
• W2051007170 cites W2017974342 @default.
• W2051007170 cites W2022387887 @default.
• W2051007170 cites W2022886857 @default.
• W2051007170 cites W2023081218 @default.
• W2051007170 cites W2023501491 @default.
• W2051007170 cites W2023529093 @default.
• W2051007170 cites W2023979631 @default.
• W2051007170 cites W2024636695 @default.
• W2051007170 cites W2027588500 @default.
• W2051007170 cites W2028682826 @default.
• W2051007170 cites W2032430743 @default.
• W2051007170 cites W2032739515 @default.
• W2051007170 cites W2041438725 @default.
• W2051007170 cites W2043788411 @default.
• W2051007170 cites W2044220354 @default.
• W2051007170 cites W2048037202 @default.
• W2051007170 cites W2048205572 @default.
• W2051007170 cites W2048888405 @default.
• W2051007170 cites W2049016731 @default.
• W2051007170 cites W2049113427 @default.
• W2051007170 cites W2049299981 @default.
• W2051007170 cites W2050716480 @default.
• W2051007170 cites W2050836998 @default.
• W2051007170 cites W2052682553 @default.
• W2051007170 cites W2054963065 @default.
• W2051007170 cites W2057355158 @default.
• W2051007170 cites W2059864937 @default.
• W2051007170 cites W2061796745 @default.
• W2051007170 cites W2062550145 @default.
• W2051007170 cites W2063122232 @default.
• W2051007170 cites W2065870694 @default.
• W2051007170 cites W2068532553 @default.
• W2051007170 cites W2069301509 @default.
• W2051007170 cites W2070058327 @default.
• W2051007170 cites W2074907255 @default.
• W2051007170 cites W2075642168 @default.
• W2051007170 cites W2078514099 @default.
• W2051007170 cites W2081302124 @default.
• W2051007170 cites W2084889414 @default.
• W2051007170 cites W2086623210 @default.
• W2051007170 cites W2086881485 @default.
• W2051007170 cites W2087467518 @default.
• W2051007170 cites W2088274839 @default.
• W2051007170 cites W2089198034 @default.
• W2051007170 cites W2090099613 @default.
• W2051007170 cites W2092499931 @default.
• W2051007170 cites W2093219983 @default.
• W2051007170 cites W2093897184 @default.
• W2051007170 cites W2100344731 @default.
• W2051007170 cites W2103903531 @default.
• W2051007170 cites W2105278734 @default.
• W2051007170 cites W2109334244 @default.
• W2051007170 cites W2109604162 @default.
• W2051007170 cites W2110673629 @default.
• W2051007170 cites W2121651624 @default.
• W2051007170 cites W2122224982 @default.
• W2051007170 cites W2122490109 @default.
• W2051007170 cites W2123476505 @default.
• W2051007170 cites W2124502418 @default.

• next