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- W2051031816 abstract "The main pathway by which mammalian cells remove DNA damage caused by UV light and some other mutagens is nucleotide excision repair (NER). The best characterised components of the human NER process are those proteins defective in the inherited disorder xeroderma pigmentosum (XP). The proteins known to be involved in the first steps of the NER reaction (damage recognition and incision–excision) are heterotrimeric RPA, XPA, the 6 to 9 subunit TFIIH, XPC-hHR23B, XPG, and ERCC1-XPF. Many interactions between these proteins have been found in recent years using different methods both in mammalian cells and for the homologous proteins in yeast. There are virtually no quantitative measurements of the relative strengths of these interactions. Higher order associations between these proteins in solution and even the existence of a complete “repairosome” complex have been reported, which would have implications both for the mechanism of repair and for the interplay between NER and other cellular processes. Nevertheless, evidence for a completely pre-assembled functional repairosome in solution is inconclusive and the order of action of repair factors on damaged DNA is uncertain." @default.
- W2051031816 created "2016-06-24" @default.
- W2051031816 creator A5065003651 @default.
- W2051031816 creator A5081633286 @default.
- W2051031816 date "1999-09-01" @default.
- W2051031816 modified "2023-09-25" @default.
- W2051031816 title "Protein complexes in nucleotide excision repair" @default.
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- W2051031816 doi "https://doi.org/10.1016/s0921-8777(99)00042-7" @default.
- W2051031816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10526214" @default.
- W2051031816 hasPublicationYear "1999" @default.
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