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- W2051034665 abstract "The genes encoding the three major targets of conventional insecticides are: Rdl , which encodes a γ–aminobutyric acid receptor subunit (RDL); para , which encodes a voltage–gated sodium channel (PARA) and Ace , which encodes insect acetylcholinesterase (AChE). Interestingly, despite the complexity of the encoded receptors or enzymes, very few amino acid residues are replaced in different resistant insects: one within RDL, two within PARA and three or more within AChE. Here we examine the possible reasons underlying this extreme conservation by looking at the aspects of receptor and/or enzyme function that may constrain replacements to such a limited number of residues." @default.
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- W2051034665 date "1998-10-29" @default.
- W2051034665 modified "2023-10-14" @default.
- W2051034665 title "Why are there so few resistance–associated mutations in insecticide target genes?" @default.
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- W2051034665 doi "https://doi.org/10.1098/rstb.1998.0319" @default.
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