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- W2051036320 abstract "Mostad and colleagues reported an association between shedding of HIV-1 cells from the cervix and vagina and use of both depot medroxyprogesterone acetate (odds ratio (OR) 2.9; 95% confidence interval (CI) 1.5-5.7) and low- and high-dose oral contraceptives (OR 3.8; 95% CI 1.4-9.9 and OR 12.3; 95% CI 1.4-101 respectively). The authors of this letter raise several methodologic concerns about the Mostad study. The investigators used odds ratios which overestimate risk when the outcome is common. Recommended instead is use of the prevalence ratio. Moreover the technique used to detect HIV-1 infected cells cannot measure free HIV-1 virions or cell-associated HIV-1 RNA. In addition because only HIV-1 DNA in infected cells was measured results could have been influenced by factors affecting the number of cells collected including hormonal contraceptive use." @default.
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- W2051036320 date "1998-01-01" @default.
- W2051036320 modified "2023-10-18" @default.
- W2051036320 title "Hormonal contraception and genital-tract shedding of HIV-1-infected cells" @default.
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- W2051036320 doi "https://doi.org/10.1016/s0140-6736(05)78234-9" @default.
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