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• W2051036333 abstract "<h3>Abstract</h3> <b>Objective:</b> To investigate the possible link between neonatal administration of intramuscular vitamin K and childhood cancer. <b>Design:</b> Ecological studies comparing incidence of cancer in groups of children classified by the vitamin K policy in operation at their hospital of birth. <b>Setting:</b> Selected large maternity units in England, Scotland, and Wales. <b>Subjects:</b> Children born in these units in varying periods between 1966 and 1991. <b>Main outcome measures:</b> Cancer occurring among these children before age 15 years identified by using the National Registry of Childhood Tumours. Ratios of observed to expected numbers of these conditions calculated for hospitals where the policy was to give all babies intramuscular vitamin K (non-selective) and where the policy was to use this treatment only for a selected minority of babies at increased risk of vitamin K deficiency bleeding (selective). <b>Results:</b> These ratios were calculated for children born in 94 hospitals with varying vitamin K policies. A raised risk was occasionally associated with vitamin K, but the overall results were not significant, and there was no evidence to support the previously suggested doubling of the risk of childhood cancer. <b>Conclusions:</b> On the basis of the results reported here it is unlikely that there is a greatly increased risk of childhood cancer attributable to intramuscular vitamin K given to newborns, if indeed there is any. <h3>Key messages</h3> Intramuscular vitamin K given to babies is known to be effective in the prevention of vitamin K deficiency bleeding but it has been suggested that these preparations, or one of their constituents, may increase the risk of childhood cancer Most studies have not shown a significant association between childhood cancer and vitamin K but are unable to exclude the possibility that its use increases the risk of childhood cancer by up to 10% Intramuscular vitamin K has been given to “high risk” babies as part of all the various prophylaxis policies in the United Kingdom; this should continue As a small risk cannot at present be excluded it seems prudent to recommend a policy of giving intramuscular vitamin K only to those babies at particularly high risk and giving it orally to others It is essential that a record should be made of whether or not vitamin K is given and of the preparation, route of administration, and dose" @default.
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• W2051036333 date "1998-01-17" @default.
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• W2051036333 title "Ecological studies of relation between hospital policies on neonatal vitamin K administration and subsequent occurrence of childhood cancer" @default.
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• W2051036333 doi "https://doi.org/10.1136/bmj.316.7126.184" @default.
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