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- W2051036765 abstract "The present report addresses the occurrence of depression during a multicenter, double-blind, randomized, placebo-controlled trial investigating the comparative anxiolytic efficacy of ipsapirone and lorazepam versus placebo in generalized anxiety disorder (GAD). Patients who entered the study scored ≥18 on the HAM-A, scored ≥ 8 on the Covi anxiety scale, and scored ⩽ 7 on the Raskin depression scale. Patients were randomized to lorazepam (2–6 mg/day), ipsapirone (10–30 mg), or placebotid for 4 weeks acute treatment. Efficacy of ipsapirone versus lorazepam and placebo in GAD was assessed with weekly HAM-A and CGI ratings. Worsening or emergence of depression was assessed with HAM-D ratings performed at baseline and weeks 2 and 4. Adverse events were assessed weekly. Ninety-six males and 161 females (age range 18–78 years) were valid for efficacy after a 4-week acute treatment period. HAM-A and CGI scores were significantly reduced with lorazepam and ipsapirone compared with placebo. HAM-D scores were also reduced significantly from baseline in the lorazepam, ipsapirone, and placebo groups; HAM-D core items significantly decreased in the ipsapirone but not in the lorazepam and placebo groups. Individual incidents of depression showed significantly (p < 0.05) higher frequency in the lorazepam group (10/104; 9.6%) compared with ipsapirone (2/106; 1.9%), but only a trend (p < 0.10) compared with placebo (4/105; 3.8%). There was an increased severity of the depressive incidents in the lorazepam group compared with the other two treatment groups. This report confirms an earlier study reporting that depression is a potential side effect of lorazepam treatment in GAD patients. Depression 1:172–176 (1993). © 1993 Wiley-Liss, Inc." @default.
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- W2051036765 date "1993-01-01" @default.
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- W2051036765 title "Depression in the course of treatment of generalized anxiety disorder with lorazepam, ipsapirone, and placebo: Results from a multicenter trial" @default.
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- W2051036765 doi "https://doi.org/10.1002/depr.3050010309" @default.
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