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• W2051047177 abstract "The levels of cytochrome P450s, cytochrome b5, NADPH-cytochrome c (P450) reductase, and three indices of monooxygenase activities (methoxyresorufin O-demethylation (MROD), ethoxycoumarin O-deethylation (ECOD), and aryl hydrocarbon hydroxylation (AHH) were compared between one insecticide-susceptible and seven MFO-mediated insecticide-resistant house fly strains. Cytochrome b5 and P450 reductase were elevated by 1.2- to 2.2-fold and 1.5- to 2.3-fold, respectively, in the resistant strains compared with the susceptible. The level of cytochrome P450s was significantly increased (up to 2.1-fold) in all except two resistant strain compared with the susceptible strain. These results support the idea that all three monooxygenase components may play a role in insecticide resistance. Levels of MROD, ECOD, and AHH were significantly elevated (up to 180-fold) in nearly all cases. Pyrethroid resistance was generally correlated with MROD and AHH activities in all except one strain." @default.
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• W2051047177 date "1990-02-01" @default.
• W2051047177 modified "2023-09-23" @default.
• W2051047177 title "Biochemical changes in the cytochrome P450 monooxygenases of seven insecticide-resistant house fly (Musca domestica L.) strains" @default.
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• W2051047177 doi "https://doi.org/10.1016/0048-3575(90)90004-l" @default.
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