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- W2051048051 abstract "The Spectra Optia CMNC procedure maintains a continuous, stable and uninterrupted MNC interface and allows operator control of final harvest volume by adjusting the collect pump flow rate. Pre-determined small volume harvests for cryopreservation have the major advantage of reducing total product/DMSO volume at re-infusion and more efficient use of cryostorage space. We collected 50 consecutive CMNC autologous harvests from 41 patients in three cohorts, progressively reducing the harvest volume at collect rates of 1.0ml/min (16), 0.8ml/min (13) and 0.6ml/min (21) for a 200minute collection period. The diagnostic groups of the three cohorts were myeloma (7,10,7), NHL/Hodgkin (6,0,7) and solid tumour (1,1,2) respectively. Patients were mobilised with chemo/G-CSF (34) or G-CSF alone (7). All patients collected sufficient progenitors for autograft and 31/41 have received their cells to date. Both median ANC to 0.5x109/l and platelet count to 20x109/l was 11 days and available for 23 (<14 days) and 20 (<18 days) patients respectively. All twelve apheresis nurses ran at least one CMNC on any of eight Optia machines available with remarkably consistent results for the 36/50 cases with pre-apheresis CD34 counts of 100ul or less, but with greater divergence at higher counts (figure). Comparison against historical data (Table) showed the highest CD34 or MNC collection efficiency (CE2%) at the 1.0ml/min collect rate comparible with Optia MNC. Collection efficiency was significantly reduced at 0.8 and 0.6ml/min but equivalent to our previous experience using COBE Spectra autoPBSC. The introduction of Optia CMNC is of great benefit to our policy of reducing the harvest volume at apheresis to permit immediate cryopreservation. Surprisingly little CD34 yield advantage was seen at 0.8ml/min compared to the greater volume reduction at 0.6ml/min and future CMNC will be 1.0ml/min or 0.6/ml/min to collect sufficient data to establish optimal settings for our routine practice." @default.
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- W2051048051 date "2015-06-01" @default.
- W2051048051 modified "2023-09-26" @default.
- W2051048051 title "Pre-determined small volume HPC-a harvests for cryopreservation using the continuous mononuclear cell (CMNC) procedure of the terumo optia apheresis machine" @default.
- W2051048051 doi "https://doi.org/10.1016/j.jcyt.2015.03.511" @default.
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