FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051048295> ?p ?o ?g. }

• W2051048295 abstract "Epstein Barr virus (EBV) infection is commonly associated with human cancer and, in particular, with lymphoid malignancies. Although the precise role of the virus in the pathogenesis of different lymphomas is largely unknown, it is well recognized that the expression of viral latent proteins and miRNA can contribute to its patoghenetic role. In this study, we compared the gene and miRNA expression profile of two EBV-associated aggressive B non-Hodgkin lymphomas known to be characterized by differential expression of the viral latent proteins aiming to dissect the possible different contribution of such proteins and EBV-encoded miRNAs. By applying extensive bioinformatic inferring and an experimental model, we found that EBV+ Burkitt lymphoma presented with significant over-expression of EBV-encoded miRNAs that were likely to contribute to its global molecular profile. On the other hand, EBV+ post transplant diffuse large B-cell lymphomas presented a significant enrichment in genes regulated by the viral latent proteins. Based on these different viral and cellular gene expression patterns, a clear distinction between EBV+ Burkitt lymphoma and post transplant diffuse large B-cell lymphomas was made. In this regard, the different viral and cellular expression patterns seemed to depend on each other, at least partially, and the latency type most probably played a significant role in their regulation. In conclusion, our data indicate that EBV influence over B-cell malignant clones may act through different mechanisms of transcriptional regulation and suggest that potentially different pathogenetic mechanisms may depend upon the conditions of the interaction between EBV and the host that finally determine the latency pattern." @default.
• W2051048295 created "2016-06-24" @default.
• W2051048295 creator A5000587388 @default.
• W2051048295 creator A5001864190 @default.
• W2051048295 creator A5007208015 @default.
• W2051048295 creator A5037413392 @default.
• W2051048295 creator A5043985252 @default.
• W2051048295 creator A5048326208 @default.
• W2051048295 creator A5057836561 @default.
• W2051048295 creator A5060740762 @default.
• W2051048295 creator A5073222946 @default.
• W2051048295 creator A5078407375 @default.
• W2051048295 creator A5079709625 @default.
• W2051048295 creator A5088076029 @default.
• W2051048295 creator A5088581133 @default.
• W2051048295 date "2014-12-23" @default.
• W2051048295 modified "2023-10-17" @default.
• W2051048295 title "Molecular signature of Epstein Barr virus-positive Burkitt lymphoma and post-transplant lymphoproliferative disorder suggest different roles for Epstein Barr virus" @default.
• W2051048295 cites W1505630375 @default.
• W2051048295 cites W1593469847 @default.
• W2051048295 cites W1603085454 @default.
• W2051048295 cites W1969433694 @default.
• W2051048295 cites W1976859150 @default.
• W2051048295 cites W1978032326 @default.
• W2051048295 cites W1981262778 @default.
• W2051048295 cites W1981951588 @default.
• W2051048295 cites W1983148576 @default.
• W2051048295 cites W1983727752 @default.
• W2051048295 cites W1989700813 @default.
• W2051048295 cites W2006646444 @default.
• W2051048295 cites W2009213326 @default.
• W2051048295 cites W2011857676 @default.
• W2051048295 cites W2014886070 @default.
• W2051048295 cites W2016466911 @default.
• W2051048295 cites W2017481656 @default.
• W2051048295 cites W2020185755 @default.
• W2051048295 cites W2020879401 @default.
• W2051048295 cites W2023509216 @default.
• W2051048295 cites W2027434506 @default.
• W2051048295 cites W2028455663 @default.
• W2051048295 cites W2034892842 @default.
• W2051048295 cites W2036194572 @default.
• W2051048295 cites W2037375415 @default.
• W2051048295 cites W2038381426 @default.
• W2051048295 cites W2042506484 @default.
• W2051048295 cites W2046541807 @default.
• W2051048295 cites W2048858264 @default.
• W2051048295 cites W2060055494 @default.
• W2051048295 cites W2065293469 @default.
• W2051048295 cites W2068118422 @default.
• W2051048295 cites W2068549702 @default.
• W2051048295 cites W2070865524 @default.
• W2051048295 cites W2071611279 @default.
• W2051048295 cites W2071649572 @default.
• W2051048295 cites W2074226088 @default.
• W2051048295 cites W2079053367 @default.
• W2051048295 cites W2079116568 @default.
• W2051048295 cites W2082496606 @default.
• W2051048295 cites W2086189629 @default.
• W2051048295 cites W2089297905 @default.
• W2051048295 cites W2090975474 @default.
• W2051048295 cites W2096203569 @default.
• W2051048295 cites W2100842411 @default.
• W2051048295 cites W2112936683 @default.
• W2051048295 cites W2115503551 @default.
• W2051048295 cites W2117092553 @default.
• W2051048295 cites W2122221708 @default.
• W2051048295 cites W2125063594 @default.
• W2051048295 cites W2125285993 @default.
• W2051048295 cites W2127305605 @default.
• W2051048295 cites W2133131759 @default.
• W2051048295 cites W2136632557 @default.
• W2051048295 cites W2137961233 @default.
• W2051048295 cites W2139713301 @default.
• W2051048295 cites W2142337569 @default.
• W2051048295 cites W2142920847 @default.
• W2051048295 cites W2143493524 @default.
• W2051048295 cites W2144490703 @default.
• W2051048295 cites W2145693548 @default.
• W2051048295 cites W2149047392 @default.
• W2051048295 cites W2149209099 @default.
• W2051048295 cites W2149522334 @default.
• W2051048295 cites W2149584454 @default.
• W2051048295 cites W2161146599 @default.
• W2051048295 cites W2204160540 @default.
• W2051048295 cites W2323003894 @default.
• W2051048295 doi "https://doi.org/10.3389/fmicb.2014.00728" @default.
• W2051048295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274971" @default.
• W2051048295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25566237" @default.
• W2051048295 hasPublicationYear "2014" @default.
• W2051048295 type Work @default.
• W2051048295 sameAs 2051048295 @default.
• W2051048295 citedByCount "28" @default.
• W2051048295 countsByYear W20510482952015 @default.
• W2051048295 countsByYear W20510482952016 @default.
• W2051048295 countsByYear W20510482952017 @default.
• W2051048295 countsByYear W20510482952018 @default.
• W2051048295 countsByYear W20510482952019 @default.
• W2051048295 countsByYear W20510482952021 @default.
• W2051048295 countsByYear W20510482952022 @default.

• next