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• W2051048821 abstract "Trace amines (TAs) such as p-tyramine, tryptamine, octopamine, and β-phenylethylamine are synthesized from amino acid precursors by aromatic amino acid decarboxylase and are enzymatically degraded by the action of monoamine oxidase A and B. The biosynthesis, chemical properties, and sublocalization of TAs are similar to classical amines including monoamines (ie, norepinephrine, dopamine, and serotonin) which are involved in the pathogenesis of mood disorders. Indeed the action mechanisms of most antidepressants are based on the regulation of such biogenic monoamines. Nonetheless, this hypothesis fails to explain the definitive comprehension of biological pathogenesis (ie, other neurotransmitters) and action mechanisms of antidepressants. In this respect, TAs may have a putative role in the development and treatment of mood disorders since they have modulation effects of release and inhibition of classical biogenic amines. This chapter will briefly review the potential role in the development and treatment for mood disorders." @default.
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• W2051048821 date "1972-02-01" @default.
• W2051048821 modified "2023-09-26" @default.
• W2051048821 title "Indoleamine metabolism in affective disorders: Excretion of tryptamine, indoleacetic acid and 5-hydroxyindoleacetic acid in depressive states" @default.
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• W2051048821 doi "https://doi.org/10.1016/0022-3999(72)90026-8" @default.
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