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- W2051064758 abstract "Seizures are the result of a sudden and temporary synchronization of neuronal activity, the reason for which is not clearly understood. Astrocytes participate in the control of neurotransmitter storage and neurotransmission efficacy. They provide fuel to neurons, which need a high level of energy to sustain normal and pathological neuronal activities, such as during epilepsy. Various genetic or induced animal models have been developed and used to study epileptogenic mechanisms. Methionine sulfoximine induces both seizures and the accumulation of brain glycogen, which might be considered as a putative energy store to neurons in various animals. Animals subjected to methionine sulfoximine develop seizures similar to the most striking form of human epilepsy, with a long pre-convulsive period of several hours, a long convulsive period during up to 48 hours and a post convulsive period during which they recover normal behavior. The accumulation of brain glycogen has been demonstrated in both the cortex and cerebellum as early as the pre-convulsive period, indicating that this accumulation is not a consequence of seizures. The accumulation results from an activation of gluconeogenesis specifically localized to astrocytes, both in vivo and in vitro. Both seizures and brain glycogen accumulation vary when using different inbred strains of mice. C57BL/6J is the most resistant strain to methionine sulfoximine, while CBA/J is the most sensitive one. The present review describes the data obtained on methionine sulfoximine dependent seizures and brain glycogen in the light of neurotransmission, highlighting the relevance of brain glycogen content in epilepsies." @default.
- W2051064758 created "2016-06-24" @default.
- W2051064758 creator A5012545190 @default.
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- W2051064758 date "2009-03-01" @default.
- W2051064758 modified "2023-09-27" @default.
- W2051064758 title "Epilepsy, Regulation of Brain Energy Metabolism and Neurotransmission" @default.
- W2051064758 cites W128151115 @default.
- W2051064758 cites W1480013346 @default.
- W2051064758 cites W1493203555 @default.
- W2051064758 cites W1503727145 @default.
- W2051064758 cites W1504555080 @default.
- W2051064758 cites W1508189994 @default.
- W2051064758 cites W1539950936 @default.
- W2051064758 cites W1542171240 @default.
- W2051064758 cites W1548862642 @default.
- W2051064758 cites W1555594295 @default.
- W2051064758 cites W1574509557 @default.
- W2051064758 cites W1628349667 @default.
- W2051064758 cites W1772857860 @default.
- W2051064758 cites W1928529925 @default.
- W2051064758 cites W1952464631 @default.
- W2051064758 cites W1964409372 @default.
- W2051064758 cites W1965056232 @default.
- W2051064758 cites W1966382524 @default.
- W2051064758 cites W1966886729 @default.
- W2051064758 cites W1968524204 @default.
- W2051064758 cites W1968671614 @default.
- W2051064758 cites W1972182945 @default.
- W2051064758 cites W1972795959 @default.
- W2051064758 cites W1975399822 @default.
- W2051064758 cites W1975440733 @default.
- W2051064758 cites W1976143339 @default.
- W2051064758 cites W1976989422 @default.
- W2051064758 cites W1977030353 @default.
- W2051064758 cites W1977294596 @default.
- W2051064758 cites W1978228545 @default.
- W2051064758 cites W1978611742 @default.
- W2051064758 cites W1978757999 @default.
- W2051064758 cites W1979738163 @default.
- W2051064758 cites W1982950909 @default.
- W2051064758 cites W1983384558 @default.
- W2051064758 cites W1983693280 @default.
- W2051064758 cites W1984232365 @default.
- W2051064758 cites W1985992749 @default.
- W2051064758 cites W1989009730 @default.
- W2051064758 cites W1989382262 @default.
- W2051064758 cites W1992231858 @default.
- W2051064758 cites W1993407843 @default.
- W2051064758 cites W1993673821 @default.
- W2051064758 cites W1995501216 @default.
- W2051064758 cites W1995978897 @default.
- W2051064758 cites W1996603253 @default.
- W2051064758 cites W1997054933 @default.
- W2051064758 cites W1997570880 @default.
- W2051064758 cites W1998367863 @default.
- W2051064758 cites W2001257014 @default.
- W2051064758 cites W2001320373 @default.
- W2051064758 cites W2004798467 @default.
- W2051064758 cites W2010994301 @default.
- W2051064758 cites W2011571485 @default.
- W2051064758 cites W2012894553 @default.
- W2051064758 cites W2012910450 @default.
- W2051064758 cites W2013297116 @default.
- W2051064758 cites W2014298077 @default.
- W2051064758 cites W2015437300 @default.
- W2051064758 cites W2015535516 @default.
- W2051064758 cites W2015892615 @default.
- W2051064758 cites W2017442183 @default.
- W2051064758 cites W2017997732 @default.
- W2051064758 cites W2020554150 @default.
- W2051064758 cites W2020869943 @default.
- W2051064758 cites W2022500753 @default.
- W2051064758 cites W2029160811 @default.
- W2051064758 cites W2029297249 @default.
- W2051064758 cites W2029473363 @default.
- W2051064758 cites W2031297664 @default.
- W2051064758 cites W2031611126 @default.
- W2051064758 cites W2031808704 @default.
- W2051064758 cites W2032542252 @default.
- W2051064758 cites W2032730787 @default.
- W2051064758 cites W2034887080 @default.
- W2051064758 cites W2036548269 @default.
- W2051064758 cites W2036697846 @default.
- W2051064758 cites W2036838450 @default.
- W2051064758 cites W2036882474 @default.
- W2051064758 cites W2037279364 @default.
- W2051064758 cites W2038123652 @default.
- W2051064758 cites W2038271220 @default.
- W2051064758 cites W2039699994 @default.
- W2051064758 cites W2040545929 @default.
- W2051064758 cites W2043403270 @default.
- W2051064758 cites W2044475482 @default.
- W2051064758 cites W2044654185 @default.
- W2051064758 cites W2044730840 @default.
- W2051064758 cites W2045530138 @default.
- W2051064758 cites W2046710865 @default.
- W2051064758 cites W2047060085 @default.