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- W2051071561 endingPage "853" @default.
- W2051071561 startingPage "839" @default.
- W2051071561 abstract "In recent years, oncologists have begun to conclude that chemotherapy has reached a plateau of efficacy as a primary treatment modality, even if toxicity can be effectively controlled. Emerging specific inhibitors of signaling and metabolic pathways (i.e., targeted agents) contrast with traditional chemotherapy drugs in that the latter primarily interfere with the DNA biosynthesis and the cell replication machinery. In an attempt to improve on the efficacy, combination of targeted drugs with conventional chemotherapeutics has become a routine way of testing multiple new agents in early phase clinical trials. This review discusses the recent advances including integrative systematic biology and RNAi approaches to counteract the chemotherapy resistance and to buttress the selectivity, efficacy and personalization of anti-cancer drug therapy." @default.
- W2051071561 created "2016-06-24" @default.
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- W2051071561 creator A5089209583 @default.
- W2051071561 date "2010-11-01" @default.
- W2051071561 modified "2023-10-16" @default.
- W2051071561 title "Chemotherapy and signaling" @default.
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