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- W2051077036 abstract "The potencies of therapeutic preparations of gonadotrophins of human, urinary origin, which comprise a heterogenous mix of isoforms with follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivities, are standardized by WHO International Standards (IS). We report here, the evaluation, through an international collaborative study, of a candidate preparation, coded 10/286, to replace the 4th IS, 98/704, for human, urinary FSH and LH (Menotrophin) which has been used for many years for the potency assignment of therapeutic preparations using bioassays. The mean FSH and LH bioactivities of 10/286, determined by in vivo bioassays in terms of 98/704, were 183 IU per ampoule (95% confidence limits 165–202) and 177 IU per ampoule (95% confidence limits 159–197), respectively." @default.
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- W2051077036 date "2013-11-01" @default.
- W2051077036 modified "2023-10-17" @default.
- W2051077036 title "Standardization of therapeutic, urinary gonadotrophins: An update on the use and availability of International Standards for Menotrophin" @default.
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- W2051077036 doi "https://doi.org/10.1016/j.biologicals.2013.08.004" @default.
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