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- W2051081260 endingPage "422" @default.
- W2051081260 startingPage "409" @default.
- W2051081260 abstract "Purpose: The recent discoveries in the field of human small heat shock proteins (sHSPs) clearly point to the important roles played by these adenosine triphosphate (ATP)-independent chaperones in the regulation of a large spectrum of vital cellular processes and in pathological diseases. These proteins are therefore considered as very attractive therapeutic targets. Aims: To understand the functions of the stress-inducible members of the sHSP family, HspB1, HspB5 and HspB8, and be able to therapeutically modulate their activities, researchers are faced with the complex oligomerisation and phosphorylation properties of these proteins and with their ability to interact with each other and with specific protein targets. Here, we have integrated, in a functionally orientated way, the up-to-date literature data concerning HspB1, HspB5 and HspB8 protein interactions which reflect their numerous crucial cellular functions. We also present data supporting the idea that specific phospho-oligomeric domains of HspB1 are involved in the interaction with particular client proteins. Conclusions: More information concerning the interactions between client protein targets and sHSPs or the multiple combinatorial chimeric oligomeric complexes formed by different sHSPs are urgently required to elaborate a comprehensive sHSPs protein interactome and propose efficient and pathology-specific therapeutic approaches." @default.
- W2051081260 created "2016-06-24" @default.
- W2051081260 creator A5004666853 @default.
- W2051081260 creator A5021759168 @default.
- W2051081260 date "2013-05-22" @default.
- W2051081260 modified "2023-10-18" @default.
- W2051081260 title "Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8" @default.
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