FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051087584> ?p ?o ?g. }

• W2051087584 endingPage "361" @default.
• W2051087584 startingPage "343" @default.
• W2051087584 abstract "Chronic pulmonary inflammation has been consistently shown to increase the risk of lung cancer. Therefore, assessing the molecular links between the two diseases and identification of chemopreventive agents that inhibit inflammation-driven lung tumorigenesis is indispensable. Female A/J mice were treated with the tobacco smoke carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and lipopolysaccharide (LPS), a potent inflammatory agent and constituent of tobacco smoke, and maintained on control diet or diet supplemented with the chemopreventive agents indole-3-carbinol (I3C) and/or silibinin (Sil). At the end of the study, mice were sacrificed and tumors on the surface of the lung were counted and gene expression levels in lung tissues were determined by RNA sequencing. The mean number of lung tumors induced by NNK and NNK + LPS was 5 and 15 tumors/mouse, respectively. Dietary supplementation with the combination of I3C and Sil significantly reduced the size and multiplicity (by 50 %) of NNK + LPS-induced lung tumors. Also, we found that 330, 2957, and 1143 genes were differentially regulated in mice treated with NNK, LPS, and NNK + LPS, respectively. The inflammatory response of lung tumors to LPS, as determined by the number of proinflammatory genes with altered gene expression or the level of alteration, was markedly less than that of normal lungs. Among 1143 genes differentially regulated in the NNK + LPS group, the expression of 162 genes and associated signaling pathways was significantly modulated by I3C and/or Sil + I3C. These genes include cytokines, chemokines, putative oncogenes and tumor suppressor genes and Ros1, AREG, EREG, Cyp1a1, Arntl, and Npas2. To our knowledge, this is the first report that provides insight into genes that are differentially expressed during inflammation-driven lung tumorigenesis and the modulation of these genes by chemopreventive agents." @default.
• W2051087584 created "2016-06-24" @default.
• W2051087584 creator A5001476935 @default.
• W2051087584 creator A5036639936 @default.
• W2051087584 creator A5047824419 @default.
• W2051087584 creator A5049136467 @default.
• W2051087584 creator A5052074792 @default.
• W2051087584 creator A5053303854 @default.
• W2051087584 creator A5072241229 @default.
• W2051087584 date "2015-03-21" @default.
• W2051087584 modified "2023-10-14" @default.
• W2051087584 title "RNA-sequencing studies identify genes differentially regulated during inflammation-driven lung tumorigenesis and targeted by chemopreventive agents" @default.
• W2051087584 cites W1576362548 @default.
• W2051087584 cites W1751092985 @default.
• W2051087584 cites W1872021546 @default.
• W2051087584 cites W1916864011 @default.
• W2051087584 cites W1964729696 @default.
• W2051087584 cites W1969061773 @default.
• W2051087584 cites W1996673634 @default.
• W2051087584 cites W2013390232 @default.
• W2051087584 cites W2015297482 @default.
• W2051087584 cites W2016397316 @default.
• W2051087584 cites W2027678100 @default.
• W2051087584 cites W2034175536 @default.
• W2051087584 cites W2043620261 @default.
• W2051087584 cites W2048270768 @default.
• W2051087584 cites W2049354897 @default.
• W2051087584 cites W2058049114 @default.
• W2051087584 cites W2071794910 @default.
• W2051087584 cites W2083832226 @default.
• W2051087584 cites W2092905174 @default.
• W2051087584 cites W2094879937 @default.
• W2051087584 cites W2096331007 @default.
• W2051087584 cites W2097906947 @default.
• W2051087584 cites W2103611039 @default.
• W2051087584 cites W2104478726 @default.
• W2051087584 cites W2109896839 @default.
• W2051087584 cites W2114104545 @default.
• W2051087584 cites W2116554142 @default.
• W2051087584 cites W2117983612 @default.
• W2051087584 cites W2119733047 @default.
• W2051087584 cites W2127639733 @default.
• W2051087584 cites W2133597000 @default.
• W2051087584 cites W2141425631 @default.
• W2051087584 cites W2146556472 @default.
• W2051087584 cites W2159114352 @default.
• W2051087584 cites W2162928593 @default.
• W2051087584 cites W2168442751 @default.
• W2051087584 cites W2169780324 @default.
• W2051087584 cites W2169961966 @default.
• W2051087584 cites W2219978888 @default.
• W2051087584 cites W4211162417 @default.
• W2051087584 doi "https://doi.org/10.1007/s00011-015-0815-z" @default.
• W2051087584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4719774" @default.
• W2051087584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25795230" @default.
• W2051087584 hasPublicationYear "2015" @default.
• W2051087584 type Work @default.
• W2051087584 sameAs 2051087584 @default.
• W2051087584 citedByCount "9" @default.
• W2051087584 countsByYear W20510875842016 @default.
• W2051087584 countsByYear W20510875842017 @default.
• W2051087584 countsByYear W20510875842019 @default.
• W2051087584 countsByYear W20510875842020 @default.
• W2051087584 countsByYear W20510875842021 @default.
• W2051087584 countsByYear W20510875842022 @default.
• W2051087584 crossrefType "journal-article" @default.
• W2051087584 hasAuthorship W2051087584A5001476935 @default.
• W2051087584 hasAuthorship W2051087584A5036639936 @default.
• W2051087584 hasAuthorship W2051087584A5047824419 @default.
• W2051087584 hasAuthorship W2051087584A5049136467 @default.
• W2051087584 hasAuthorship W2051087584A5052074792 @default.
• W2051087584 hasAuthorship W2051087584A5053303854 @default.
• W2051087584 hasAuthorship W2051087584A5072241229 @default.
• W2051087584 hasBestOaLocation W20510875842 @default.
• W2051087584 hasConcept C104317684 @default.
• W2051087584 hasConcept C114246631 @default.
• W2051087584 hasConcept C126322002 @default.
• W2051087584 hasConcept C13373296 @default.
• W2051087584 hasConcept C164027704 @default.
• W2051087584 hasConcept C203014093 @default.
• W2051087584 hasConcept C2776256026 @default.
• W2051087584 hasConcept C2776914184 @default.
• W2051087584 hasConcept C2777714996 @default.
• W2051087584 hasConcept C502942594 @default.
• W2051087584 hasConcept C55493867 @default.
• W2051087584 hasConcept C555283112 @default.
• W2051087584 hasConcept C71924100 @default.
• W2051087584 hasConcept C86803240 @default.
• W2051087584 hasConceptScore W2051087584C104317684 @default.
• W2051087584 hasConceptScore W2051087584C114246631 @default.
• W2051087584 hasConceptScore W2051087584C126322002 @default.
• W2051087584 hasConceptScore W2051087584C13373296 @default.
• W2051087584 hasConceptScore W2051087584C164027704 @default.
• W2051087584 hasConceptScore W2051087584C203014093 @default.
• W2051087584 hasConceptScore W2051087584C2776256026 @default.
• W2051087584 hasConceptScore W2051087584C2776914184 @default.
• W2051087584 hasConceptScore W2051087584C2777714996 @default.
• W2051087584 hasConceptScore W2051087584C502942594 @default.

• next