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• W2051102637 abstract "Central post-stroke pain (CPSP) is a neuropathic pain syndrome that often develops in a delayed manner after thalamic stroke. Here, we describe a new model of CPSP by stereotaxic thalamic injection of endothelin-1. Stroke rats ( n = 12), but not saline-injected controls ( n = 12), developed a progressive, contralateral cutaneous thermal hyperalgesia over 4 weeks, without motor deficits. Lesions were highly focal and mainly affected the ventral posterior thalamic complex. Tchis model reproduces the infarct location and delayed hypersensitivity typical of CPSP, and may be useful to investigate its pathophysiology and test therapies targeting recovery and pain after thalamic stroke." @default.
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• W2051102637 date "2015-04-22" @default.
• W2051102637 modified "2023-10-14" @default.
• W2051102637 title "Late-Onset Thermal Hypersensitivity after Focal Ischemic Thalamic Infarcts as a Model for Central Post-Stroke Pain in Rats" @default.
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• W2051102637 doi "https://doi.org/10.1038/jcbfm.2015.73" @default.
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