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• W2051103571 endingPage "2193" @default.
• W2051103571 startingPage "2182" @default.
• W2051103571 abstract "ABSTRACT The Saccharomyces cerevisiae Ku complex, while important for nonhomologous DNA end joining, is also necessary for maintaining wild-type telomere length and a normal chromosomal DNA end structure. Yeast cells lacking Ku can grow at 23°C but are unable to do so at elevated temperatures due to an activation of DNA damage checkpoints. To gain insights into the mechanisms affected by temperature in such strains, we isolated and characterized a new allele of the YKU70 gene, yku70 - 30 ts . By several criteria, the Yku70-30p protein is functional at 23°C and nonfunctional at 37°C. The analyses of telomeric repeat maintenance as well as the terminal DNA end structure in strains harboring this allele alone or in strains with a combination of other mutations affecting telomere maintenance show that the altered DNA end structure in yeast cells lacking Ku is not generated in a telomerase-dependent fashion. Moreover, the single-stranded G-rich DNA on such telomeres is not detected by DNA damage checkpoints to arrest cell growth, provided that there are sufficient double-stranded telomeric repeats present. The results also demonstrate that mutations in genes negatively affecting G-strand synthesis (e.g., RIF1 ) or C-strand synthesis (e.g., the DNA polymerase α gene) allow for the maintenance of longer telomeric repeat tracts in cells lacking Ku. Finally, extending telomeric repeat tracts in such cells at least temporarily suppresses checkpoint activation and growth defects at higher temperatures. Thus, we hypothesize that an aspect of the coordinated synthesis of double-stranded telomeric repeats is sensitive to elevated temperatures." @default.
• W2051103571 created "2016-06-24" @default.
• W2051103571 creator A5002272836 @default.
• W2051103571 creator A5086237620 @default.
• W2051103571 date "2002-04-01" @default.
• W2051103571 modified "2023-09-26" @default.
• W2051103571 title "Maintenance of Double-Stranded Telomeric Repeats as the Critical Determinant for Cell Viability in Yeast Cells Lacking Ku" @default.
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• W2051103571 doi "https://doi.org/10.1128/mcb.22.7.2182-2193.2002" @default.
• W2051103571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/133694" @default.
• W2051103571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11884605" @default.
• W2051103571 hasPublicationYear "2002" @default.
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