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• W2051140797 abstract "The syntheses of enaniomeric threo- and erythro-1,2-diamino-1-phenylpropanes (Ph/Me) and of the racemic 1,2-diaminophenylethane (Ph/H) are described. These diamines and related N2-methyl- and N1,N2-dimethyl-1,2-diamino-1-phenylpropanes were transformed into dichloroplatinum(II) complexes.(Ph/HPtCl2, Ph/MePtCl2, Ph/MeMePtCl2, Ph/Me-Dime-PtCl2). For the 1H NMR spectroscopical determination of their optical purity the diamines (Ph/Me) were converted with (R)-myrtenal into their diimines. In the test on the MCF-7 breast cancer cell line (R,R)-Ph/MePtCl2 produced the strongest effect of all new complexes, comparable with that of the standard cisplatin and of other Pt complexes. Its enantiomer (S,S)-Ph/MePtCl2 possessed a distinctly weaker inhibitory potency while the erythro-configurated counterparts were even less active [(R,R)>(S,S))>(S,R,)=(R,S)]. All N2-methylated and N1,N2-dimethylated complexes (Ph/MeMePtCl2, Ph/Me-Dime-PtCl2) showed comparale activities equaling those of (R,S), and (S,R))-Ph/MePtCl2. The molecular reasons for the differing potencies of the diastereomeric and enantiomeric Ph/MePtCl2 complexes are discussed in consideration of the complex conformation." @default.
• W2051140797 created "2016-06-24" @default.
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• W2051140797 date "1997-11-01" @default.
• W2051140797 modified "2023-09-26" @default.
• W2051140797 title "The stereoselectivity of antitumor active [1,2-diamino-1-phenylpropane]dichloroplatinum(II) complexes" @default.
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• W2051140797 doi "https://doi.org/10.1016/s0020-1693(97)05603-x" @default.
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