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- W2051147724 abstract "Chick–quail chimeric studies were made to determine the origin of the cells of splenic ellipsoid. The ellipsoid is formed by supporting and phagocytic cells, which are embedded in a well-organized extracellular matrix. Splenic and bursal anlage of 6- to 6.5-day-old quail embryos were transplanted into the coelomic cavity of 3-day-old chick embryos and further incubated for 17 days. CD45+ chicken hemopoietic cells colonized both organs. They formed the cells of the ellipsoid and the periellipsoidal white pulp of the transplanted quail spleen. Chicken-specific collagen III was produced only in the donor quail spleen, but not in the bursa of Fabricius. The CD45+/collagen I+/collagen III+ cells are probably identical with the mammalian peripheral blood fibrocytes and contribute to the formation of supporting cells, whereas the CD45+/74.2+ ellipsoid-associated macrophages are of monocytic origin. We provide, for the first time, experimental evidence that peripheral blood fibrocytes exist in the avian species; they are present in the circulation of the chicken embryo and contribute to the organogenesis of the spleen. Developmental Dynamics 232:55–66, 2005. © 2004 Wiley-Liss, Inc." @default.
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- W2051147724 date "2004-12-03" @default.
- W2051147724 modified "2023-10-15" @default.
- W2051147724 title "Peripheral blood fibrocytes contribute to the formation of the avian spleen" @default.
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- W2051147724 doi "https://doi.org/10.1002/dvdy.20212" @default.
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