FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051166727> ?p ?o ?g. }

• W2051166727 abstract "To image inflammation sites, we developed a novel nanoparticle, hydroxylamine-containing nanoparticle (HANP), which emits an intense electron spin resonance (ESR)-signal triggered by enzymatic oxidation reaction and pH-sensitive self-disintegration. The nanoparticle was prepared from an amphiphilic block copolymer, poly(ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-1-hydroxyl)aminomethylstyrene] (PEG-b-PMNT-H), which spontaneously forms a core–shell type polymeric micelle (particle diameter = ca. 50 nm) in aqueous media. Because the PMNT-H segment in the block copolymer possesses amino groups in each repeating unit, the particle can be disintegrated by protonation of the amino groups in an acidic pH environment such as inflammation sites, which is confined to the hydrophobic core of HANP. Mixing HANP with horseradish peroxidase (HRP)/H2O2 mixture resulted in enzymatic oxidization of the hydroxylamines in the PEG-b-PMNT-H and converted the hydroxylamine to the stable nitroxide radical form in PEG-b-poly[4-(2,2,6,6-tetramethylpiperidine-1-oxyl)aminomethylstyrene] (PEG-b-PMNT), which shows an intense ESR signal. It is interesting to note that the ESR signal increased at a greater rate under acidic conditions (pH 5.6) than that under neutral conditions (pH 7.4), although the enzymatic activity of HRP under neutral conditions is known to be much higher than that under acidic conditions. This indicates that enzymatic oxidation reaction was accelerated by synchronizing the disintegration of HANP under acidic conditions. On the basis of these results, HANP can be used as a high-performance ESR probe for imaging of inflammation sites." @default.
• W2051166727 created "2016-06-24" @default.
• W2051166727 creator A5058356276 @default.
• W2051166727 creator A5058982278 @default.
• W2051166727 date "2012-02-09" @default.
• W2051166727 modified "2023-09-29" @default.
• W2051166727 title "Design and Preparation of a Nanoprobe for Imaging Inflammation Sites" @default.
• W2051166727 cites W1597643123 @default.
• W2051166727 cites W1823279151 @default.
• W2051166727 cites W1965037168 @default.
• W2051166727 cites W1975429911 @default.
• W2051166727 cites W1976822272 @default.
• W2051166727 cites W1976881963 @default.
• W2051166727 cites W1985481708 @default.
• W2051166727 cites W1989704200 @default.
• W2051166727 cites W1996373524 @default.
• W2051166727 cites W2000954855 @default.
• W2051166727 cites W2008995145 @default.
• W2051166727 cites W2014987477 @default.
• W2051166727 cites W2034854188 @default.
• W2051166727 cites W2037266969 @default.
• W2051166727 cites W2038519968 @default.
• W2051166727 cites W2045120677 @default.
• W2051166727 cites W2046396329 @default.
• W2051166727 cites W2054462119 @default.
• W2051166727 cites W2064743984 @default.
• W2051166727 cites W2079558068 @default.
• W2051166727 cites W2080019161 @default.
• W2051166727 cites W2082742022 @default.
• W2051166727 cites W2083376919 @default.
• W2051166727 cites W2088199433 @default.
• W2051166727 cites W2092225471 @default.
• W2051166727 cites W2121469147 @default.
• W2051166727 cites W2137338529 @default.
• W2051166727 cites W2161735736 @default.
• W2051166727 cites W229017931 @default.
• W2051166727 doi "https://doi.org/10.1007/s13758-011-0007-5" @default.
• W2051166727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22589050" @default.
• W2051166727 hasPublicationYear "2012" @default.
• W2051166727 type Work @default.
• W2051166727 sameAs 2051166727 @default.
• W2051166727 citedByCount "8" @default.
• W2051166727 countsByYear W20511667272013 @default.
• W2051166727 countsByYear W20511667272014 @default.
• W2051166727 countsByYear W20511667272016 @default.
• W2051166727 countsByYear W20511667272017 @default.
• W2051166727 countsByYear W20511667272018 @default.
• W2051166727 countsByYear W20511667272020 @default.
• W2051166727 countsByYear W20511667272022 @default.
• W2051166727 crossrefType "journal-article" @default.
• W2051166727 hasAuthorship W2051166727A5058356276 @default.
• W2051166727 hasAuthorship W2051166727A5058982278 @default.
• W2051166727 hasBestOaLocation W20511667271 @default.
• W2051166727 hasConcept C10138342 @default.
• W2051166727 hasConcept C11268172 @default.
• W2051166727 hasConcept C121332964 @default.
• W2051166727 hasConcept C139066938 @default.
• W2051166727 hasConcept C145148216 @default.
• W2051166727 hasConcept C155672457 @default.
• W2051166727 hasConcept C15920480 @default.
• W2051166727 hasConcept C162324750 @default.
• W2051166727 hasConcept C171250308 @default.
• W2051166727 hasConcept C178790620 @default.
• W2051166727 hasConcept C181199279 @default.
• W2051166727 hasConcept C184651966 @default.
• W2051166727 hasConcept C185592680 @default.
• W2051166727 hasConcept C187961010 @default.
• W2051166727 hasConcept C188027245 @default.
• W2051166727 hasConcept C192562407 @default.
• W2051166727 hasConcept C2775999725 @default.
• W2051166727 hasConcept C2777516009 @default.
• W2051166727 hasConcept C2777676563 @default.
• W2051166727 hasConcept C30095370 @default.
• W2051166727 hasConcept C46141821 @default.
• W2051166727 hasConcept C521977710 @default.
• W2051166727 hasConcept C54400483 @default.
• W2051166727 hasConcept C67407626 @default.
• W2051166727 hasConceptScore W2051166727C10138342 @default.
• W2051166727 hasConceptScore W2051166727C11268172 @default.
• W2051166727 hasConceptScore W2051166727C121332964 @default.
• W2051166727 hasConceptScore W2051166727C139066938 @default.
• W2051166727 hasConceptScore W2051166727C145148216 @default.
• W2051166727 hasConceptScore W2051166727C155672457 @default.
• W2051166727 hasConceptScore W2051166727C15920480 @default.
• W2051166727 hasConceptScore W2051166727C162324750 @default.
• W2051166727 hasConceptScore W2051166727C171250308 @default.
• W2051166727 hasConceptScore W2051166727C178790620 @default.
• W2051166727 hasConceptScore W2051166727C181199279 @default.
• W2051166727 hasConceptScore W2051166727C184651966 @default.
• W2051166727 hasConceptScore W2051166727C185592680 @default.
• W2051166727 hasConceptScore W2051166727C187961010 @default.
• W2051166727 hasConceptScore W2051166727C188027245 @default.
• W2051166727 hasConceptScore W2051166727C192562407 @default.
• W2051166727 hasConceptScore W2051166727C2775999725 @default.
• W2051166727 hasConceptScore W2051166727C2777516009 @default.
• W2051166727 hasConceptScore W2051166727C2777676563 @default.
• W2051166727 hasConceptScore W2051166727C30095370 @default.
• W2051166727 hasConceptScore W2051166727C46141821 @default.
• W2051166727 hasConceptScore W2051166727C521977710 @default.
• W2051166727 hasConceptScore W2051166727C54400483 @default.

• next