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• W2051174823 abstract "Well over a decade ago Visconti and Delbriuck proposed' that bacteriophage chromosomes mate pairwise and randomly with respect to partner within the vegetative pool. No data have arisen since to seriously fault these assumptions. However, the details of pairwise mating have never been very closely examined. Since appropriate cytological examinations of recombining phage chromosomes have not yet been performed, and since there is no compelling evidence to suggest that phage chromosomes pair as extensively as do meiotic eukaryotic chromosomes, a measurement has been sought of the extent of pairing in bacteriophage T4. This pairing has been defined purely in terms of genetic recombination. We show here that it involves only a tiny fraction of the phage chromosome. Rationale.-Two phages carrying close point mutant markers are crossed, and the wild-type recombinants are scored. Low multiplicities of infection are used, so that recombinants generally arise from cells infected with only one of each parental phage. In addition, however, a third parental phage is included in the same cross at a high multiplicity of infection. On the assumption that mating is random with respect to partner, most pairwise matings which involve one of the minority parents will also involve one of the majority parents. If a majority parent is chosen which carries both point mutant markers, the frequency of wild-type recombinants will thereby be sharply reduced. What then will be the result if the majority parent contains a deletion of the entire region bounded by the two point mutant markers? If the deletion is shorter than the chromosome length which is usually involved in recombinational pairing (the pairing region), then the deletion will produce the same effect as does the double point mutant. If the deletion is longer than the pairing region, pairwise interactions between minority and majority parents within this region will cease. The two minority parents will then be able to interact within this region, and wild-type recombinants will be produced at an increased frequency. The expected frequencies W of wild-type recombinants may be estimated starting from the general principles of the Visconti-Delbruick theory: W = FDP, where F is the probability that two interacting chromosomes will be the two minority parents, D is the probability of recombining a given pair of markers between interacting chromosomes, and P is the probability that an infected cell will be infected with at least one of each of the minority parents. Since D is constant for a given pair of markers, we will calculate the quantity W/D. Assuming a random distribution of infecting phages among the cells, P = (1 em1) (1 e-m2)/(l emI + m2 + m%) where mi, M2, and m3 are the multiplicities of infection of the two minority parents and the majority parent, respectively. The form of F will depend upon the degree of interaction between minority and majority parents. If the interaction is unrestricted, as when the majority parent carries both point mutant markers, F = f2, where fi and f2 are the fractional multiplicities of the minority" @default.
• W2051174823 created "2016-06-24" @default.
• W2051174823 creator A5067192980 @default.
• W2051174823 date "1967-09-01" @default.
• W2051174823 modified "2023-10-17" @default.
• W2051174823 title "The length of the homologous pairing region for genetic recombination in bacteriophage T4." @default.
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• W2051174823 doi "https://doi.org/10.1073/pnas.58.3.962" @default.
• W2051174823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/335732" @default.
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