FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051179313> ?p ?o ?g. }

• W2051179313 endingPage "409" @default.
• W2051179313 startingPage "402" @default.
• W2051179313 abstract "Midazolam maleate is a new water soluble benzodiazepine used for induction of anaesthesia. Ten patients with symptomatic ischaemic heart disease were premedicated intramuscularly with morphine 0.l mg · kg-1 and scopolamine 6–8 µg · kg-1, 60–90 minutes before induction. The heart rate, systolic/diastolic blood pressure, mean systolic blood pressure, mean pulmonary artery blood pressure, pulmonary artery occluded pressure, mean right atrial pressure, cardiac output (duplicate thermodilution) and arterial blood gas tensions were measured at four time periods: (1) after instrumentation while breathing room air, (2) after transfer to the operating room while breathing 100 percent oxygen by mask, (3) one to two minutes after intravenous midazolam maleate 0.2 mg · kg-1 and (4) four to five minutes after midazolam maleate. The cardiac index, stroke index, heart ratesystolic blood pressure product, systemic vascular resistance index, pulmonary vascular resistance index, left ventricular stroke work index and right ventricular stroke work index were calculated for each of the study time-periods from the measured parameters. Midazolam maleate anaesthetized all patients and times for induction ranged from 30 to 90 seconds (mean 44). Apnoea occurred in 75 per cent of patients and ventilation was assisted in those instances. The $$Pa_{o_2 } $$ was unchanged by midazolam maleate, but the $$Pa_{co_2 } $$ rose significantly (p < 0.02) from 5.32 ± 0.19 to 5.85 ± 0.17kPa(40 ± 1.4 to 44 ± 1.3 mm Hg) (1–2 min) and 6.1 ± 0.17 kPa (46 ± 1.3 mm Hg) (4–5 minutes after midazolam maleate). Haemodynamic effects of midazolam maleate were minor and in most cases less than those associated with transfer of the patients to the operating room when the systemic systolic/diastolic blood pressure, mean systemic blood pressure, mean right atrial pressure, pulmonary artery occluded pressure and systemic vascular resistance index alt significantly increased (p < 0.01). Midazolam maleate significantly reduced systemic systolic/diastolic pressure, mean systemic blood pressure, stroke volume, left and right ventricular stroke work index and systemic vascular resistance index toward the original resting control. The heart rate rose from 55 ± 6.6 to 66 ± 5.3 beats per minute (p < 0.01) one to two minutes after midazolam maleate, and the mean right atrial pressure, mean pulmonary artery pressure, pulmonary artery occluded pressure, cardiac index, stroke index, pulmonary vascular resistance index and heart rate-systolic blood pressure product remained unchanged. There were no further significant changes four to five minutes after midazolam maleate, except in systemic systolic/diastolic pressure which continued to decline to the level of the resting control (125/61). It is concluded that the rapid action of midazolam maleate and its modest effects on haemodynamic parameters, make it a safe and efficacious induction agent in patients with ischaemic heart disease." @default.
• W2051179313 created "2016-06-24" @default.
• W2051179313 creator A5007074446 @default.
• W2051179313 creator A5032667313 @default.
• W2051179313 creator A5041131334 @default.
• W2051179313 date "1979-09-01" @default.
• W2051179313 modified "2023-09-27" @default.
• W2051179313 title "Midazolam maleate induction in patients with ischaemic heart disease: Haemodynamic observations" @default.
• W2051179313 cites W1969209018 @default.
• W2051179313 cites W1991064387 @default.
• W2051179313 cites W2006805901 @default.
• W2051179313 cites W2021514880 @default.
• W2051179313 cites W2027613907 @default.
• W2051179313 cites W2034797443 @default.
• W2051179313 cites W2046215109 @default.
• W2051179313 cites W2049691579 @default.
• W2051179313 cites W2052035700 @default.
• W2051179313 cites W2083225549 @default.
• W2051179313 cites W2088796249 @default.
• W2051179313 cites W2115945083 @default.
• W2051179313 cites W2151933013 @default.
• W2051179313 cites W2339147221 @default.
• W2051179313 cites W2402433594 @default.
• W2051179313 cites W2412412837 @default.
• W2051179313 cites W2443088650 @default.
• W2051179313 doi "https://doi.org/10.1007/bf03006455" @default.
• W2051179313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/487235" @default.
• W2051179313 hasPublicationYear "1979" @default.
• W2051179313 type Work @default.
• W2051179313 sameAs 2051179313 @default.
• W2051179313 citedByCount "92" @default.
• W2051179313 countsByYear W20511793132013 @default.
• W2051179313 countsByYear W20511793132017 @default.
• W2051179313 countsByYear W20511793132018 @default.
• W2051179313 countsByYear W20511793132021 @default.
• W2051179313 crossrefType "journal-article" @default.
• W2051179313 hasAuthorship W2051179313A5007074446 @default.
• W2051179313 hasAuthorship W2051179313A5032667313 @default.
• W2051179313 hasAuthorship W2051179313A5041131334 @default.
• W2051179313 hasBestOaLocation W20511793131 @default.
• W2051179313 hasConcept C126322002 @default.
• W2051179313 hasConcept C139940330 @default.
• W2051179313 hasConcept C164705383 @default.
• W2051179313 hasConcept C178853913 @default.
• W2051179313 hasConcept C2776814716 @default.
• W2051179313 hasConcept C2777953023 @default.
• W2051179313 hasConcept C2778000748 @default.
• W2051179313 hasConcept C31861589 @default.
• W2051179313 hasConcept C42219234 @default.
• W2051179313 hasConcept C58245268 @default.
• W2051179313 hasConcept C71924100 @default.
• W2051179313 hasConcept C84393581 @default.
• W2051179313 hasConceptScore W2051179313C126322002 @default.
• W2051179313 hasConceptScore W2051179313C139940330 @default.
• W2051179313 hasConceptScore W2051179313C164705383 @default.
• W2051179313 hasConceptScore W2051179313C178853913 @default.
• W2051179313 hasConceptScore W2051179313C2776814716 @default.
• W2051179313 hasConceptScore W2051179313C2777953023 @default.
• W2051179313 hasConceptScore W2051179313C2778000748 @default.
• W2051179313 hasConceptScore W2051179313C31861589 @default.
• W2051179313 hasConceptScore W2051179313C42219234 @default.
• W2051179313 hasConceptScore W2051179313C58245268 @default.
• W2051179313 hasConceptScore W2051179313C71924100 @default.
• W2051179313 hasConceptScore W2051179313C84393581 @default.
• W2051179313 hasIssue "5" @default.
• W2051179313 hasLocation W20511793131 @default.
• W2051179313 hasLocation W20511793132 @default.
• W2051179313 hasOpenAccess W2051179313 @default.
• W2051179313 hasPrimaryLocation W20511793131 @default.
• W2051179313 hasRelatedWork W1977774560 @default.
• W2051179313 hasRelatedWork W2025123971 @default.
• W2051179313 hasRelatedWork W2053809643 @default.
• W2051179313 hasRelatedWork W2056490458 @default.
• W2051179313 hasRelatedWork W2119432976 @default.
• W2051179313 hasRelatedWork W2252537276 @default.
• W2051179313 hasRelatedWork W2322635498 @default.
• W2051179313 hasRelatedWork W2406854482 @default.
• W2051179313 hasRelatedWork W2414821663 @default.
• W2051179313 hasRelatedWork W2469397725 @default.
• W2051179313 hasVolume "26" @default.
• W2051179313 isParatext "false" @default.
• W2051179313 isRetracted "false" @default.
• W2051179313 magId "2051179313" @default.
• W2051179313 workType "article" @default.