Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051200513> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2051200513 endingPage "1582" @default.
- W2051200513 startingPage "1579" @default.
- W2051200513 abstract "Objectives: The current study attempts to evaluate the effectiveness of methotrexate infusion therapy in the management of low-risk gestational trophoblastic disease and to find out whether an increase in the dose intensity can effect a faster remission and a shorter treatment duration. Study Design: This is a prospective study. Between June 1990 and August 1998, 59 patients with low-risk trophoblastic disease were treated with methotrexate at a dose of 100 mg/m2 as an intravenous bolus over 30 minutes followed by a 12-hour infusion of methotrexate at a dose of 200 mg/m2. Folinic acid was not given unless the serum methotrexate reached a toxic level 24 hours after infusion (toxic level, 10 μmol/L). Actinomycin D was added in patients with a partial response. The follow-up period of these patients ranged from 12 to 113 months, with a median of 58.5 months and a mean of 55.7 months. Results: Fifty-four patients attained a complete biochemical remission. Twenty-eight patients went into biochemical remission after one methotrexate infusion. Five patients showed a partial biochemical response. A relapse developed in 2 of the 54 complete responders at 3 months and 18 months after the initial therapy. Both patients received combination therapy consisting of methotrexate, etoposide, and bleomycin. They went into biochemical remission and have remained disease-free at the time of analysis. All of the 59 patients were in biochemical remission at the time of analysis. No significant side effects were observed except that Stevens-Johnson syndrome developed in 1 patient. Conclusions: Methotrexate infusion therapy described in this study is effective in the treatment of low-risk gestational trophoblastic disease. The omission of consolidation therapy and folinic acid rescue decreases the cost and duration of treatment. (Am J Obstet Gynecol 2000;183:1579-82.)" @default.
- W2051200513 created "2016-06-24" @default.
- W2051200513 creator A5030510623 @default.
- W2051200513 creator A5040172079 @default.
- W2051200513 creator A5047335212 @default.
- W2051200513 creator A5058816598 @default.
- W2051200513 date "2000-12-01" @default.
- W2051200513 modified "2023-10-10" @default.
- W2051200513 title "Methotrexate infusion in low-risk gestational trophoblastic disease" @default.
- W2051200513 cites W1516925799 @default.
- W2051200513 cites W1523520347 @default.
- W2051200513 cites W1909111805 @default.
- W2051200513 cites W2000817015 @default.
- W2051200513 cites W2012630846 @default.
- W2051200513 cites W2013735394 @default.
- W2051200513 cites W2023952758 @default.
- W2051200513 cites W2030289347 @default.
- W2051200513 cites W2031374937 @default.
- W2051200513 cites W2042261295 @default.
- W2051200513 cites W2044229996 @default.
- W2051200513 cites W2059164223 @default.
- W2051200513 cites W2067227968 @default.
- W2051200513 cites W2106612113 @default.
- W2051200513 doi "https://doi.org/10.1067/mob.2000.108077" @default.
- W2051200513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11120531" @default.
- W2051200513 hasPublicationYear "2000" @default.
- W2051200513 type Work @default.
- W2051200513 sameAs 2051200513 @default.
- W2051200513 citedByCount "30" @default.
- W2051200513 countsByYear W20512005132012 @default.
- W2051200513 countsByYear W20512005132014 @default.
- W2051200513 countsByYear W20512005132021 @default.
- W2051200513 countsByYear W20512005132022 @default.
- W2051200513 crossrefType "journal-article" @default.
- W2051200513 hasAuthorship W2051200513A5030510623 @default.
- W2051200513 hasAuthorship W2051200513A5040172079 @default.
- W2051200513 hasAuthorship W2051200513A5047335212 @default.
- W2051200513 hasAuthorship W2051200513A5058816598 @default.
- W2051200513 hasConcept C126322002 @default.
- W2051200513 hasConcept C141071460 @default.
- W2051200513 hasConcept C2776232574 @default.
- W2051200513 hasConcept C2776694085 @default.
- W2051200513 hasConcept C2778119113 @default.
- W2051200513 hasConcept C2778376644 @default.
- W2051200513 hasConcept C2779234561 @default.
- W2051200513 hasConcept C2779804826 @default.
- W2051200513 hasConcept C2780456651 @default.
- W2051200513 hasConcept C2781059491 @default.
- W2051200513 hasConcept C54355233 @default.
- W2051200513 hasConcept C71924100 @default.
- W2051200513 hasConcept C86803240 @default.
- W2051200513 hasConcept C90924648 @default.
- W2051200513 hasConceptScore W2051200513C126322002 @default.
- W2051200513 hasConceptScore W2051200513C141071460 @default.
- W2051200513 hasConceptScore W2051200513C2776232574 @default.
- W2051200513 hasConceptScore W2051200513C2776694085 @default.
- W2051200513 hasConceptScore W2051200513C2778119113 @default.
- W2051200513 hasConceptScore W2051200513C2778376644 @default.
- W2051200513 hasConceptScore W2051200513C2779234561 @default.
- W2051200513 hasConceptScore W2051200513C2779804826 @default.
- W2051200513 hasConceptScore W2051200513C2780456651 @default.
- W2051200513 hasConceptScore W2051200513C2781059491 @default.
- W2051200513 hasConceptScore W2051200513C54355233 @default.
- W2051200513 hasConceptScore W2051200513C71924100 @default.
- W2051200513 hasConceptScore W2051200513C86803240 @default.
- W2051200513 hasConceptScore W2051200513C90924648 @default.
- W2051200513 hasIssue "6" @default.
- W2051200513 hasLocation W20512005131 @default.
- W2051200513 hasLocation W20512005132 @default.
- W2051200513 hasOpenAccess W2051200513 @default.
- W2051200513 hasPrimaryLocation W20512005131 @default.
- W2051200513 hasRelatedWork W1523520347 @default.
- W2051200513 hasRelatedWork W173258367 @default.
- W2051200513 hasRelatedWork W2013735394 @default.
- W2051200513 hasRelatedWork W2020618832 @default.
- W2051200513 hasRelatedWork W2060496388 @default.
- W2051200513 hasRelatedWork W2068695759 @default.
- W2051200513 hasRelatedWork W2378849607 @default.
- W2051200513 hasRelatedWork W2408950686 @default.
- W2051200513 hasRelatedWork W2772685935 @default.
- W2051200513 hasRelatedWork W4383460907 @default.
- W2051200513 hasVolume "183" @default.
- W2051200513 isParatext "false" @default.
- W2051200513 isRetracted "false" @default.
- W2051200513 magId "2051200513" @default.
- W2051200513 workType "article" @default.