Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051200733> ?p ?o ?g. }
- W2051200733 endingPage "853" @default.
- W2051200733 startingPage "847" @default.
- W2051200733 abstract "Neovascularization is involved in beneficial and detrimental processes of tendon pathology. We investigated the influence of repetitive motion on the expression of the most important angiogenic factor, the vascular endothelial growth factor (VEGF) in the 3T3 NIH fibroblast cell line and in cultures of rat Achilles tendon fibroblasts. Monolayers of subconfluently grown cells were stretched in rectangular silicone dishes with cyclic uniaxial movement. Strain was applied over 24 h varying the frequency (0.5–1 Hz). Fibroblasts (3T3 fibroblasts and rat Achilles tendon cultures) cultivated without the application of cyclic strain released measurable VEGF amounts into their culture supernatants. Cyclic stretching of the cells with a frequency of 1 Hz resulted in an increased expression of VEGF. A low frequency (0.5 Hz) reduced VEGF expression to control levels. RT PCR revealed VEGF 121 and VEGF 165 as the only splice forms that were induced by cyclic stretching. Western blot experiments could further show that cyclic stretching induced activation of the transcription factor HIF-1α. These results demonstrate that mechanical factors are involved in the regulation of VEGF expression in tendon tissue. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved." @default.
- W2051200733 created "2016-06-24" @default.
- W2051200733 creator A5003040527 @default.
- W2051200733 creator A5009550643 @default.
- W2051200733 creator A5017431385 @default.
- W2051200733 creator A5039656929 @default.
- W2051200733 creator A5057789441 @default.
- W2051200733 creator A5078398391 @default.
- W2051200733 date "2004-07-01" @default.
- W2051200733 modified "2023-10-16" @default.
- W2051200733 title "Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1α) in tendon fibroblasts" @default.
- W2051200733 cites W1594190685 @default.
- W2051200733 cites W1667085792 @default.
- W2051200733 cites W1869810523 @default.
- W2051200733 cites W1952078600 @default.
- W2051200733 cites W1969116652 @default.
- W2051200733 cites W1970086540 @default.
- W2051200733 cites W1970819764 @default.
- W2051200733 cites W1971425596 @default.
- W2051200733 cites W197882401 @default.
- W2051200733 cites W1983838735 @default.
- W2051200733 cites W1989704413 @default.
- W2051200733 cites W1990409165 @default.
- W2051200733 cites W1994866601 @default.
- W2051200733 cites W1996028216 @default.
- W2051200733 cites W1998506611 @default.
- W2051200733 cites W2002049222 @default.
- W2051200733 cites W2012399324 @default.
- W2051200733 cites W2013594557 @default.
- W2051200733 cites W2019989758 @default.
- W2051200733 cites W2022140257 @default.
- W2051200733 cites W2032329435 @default.
- W2051200733 cites W2033964400 @default.
- W2051200733 cites W2035024999 @default.
- W2051200733 cites W2036857231 @default.
- W2051200733 cites W2037517508 @default.
- W2051200733 cites W2038449972 @default.
- W2051200733 cites W2039647862 @default.
- W2051200733 cites W2043024818 @default.
- W2051200733 cites W2047004508 @default.
- W2051200733 cites W2047471761 @default.
- W2051200733 cites W2048625931 @default.
- W2051200733 cites W2050192868 @default.
- W2051200733 cites W2055284636 @default.
- W2051200733 cites W2059907694 @default.
- W2051200733 cites W2062594120 @default.
- W2051200733 cites W2063076489 @default.
- W2051200733 cites W2067529354 @default.
- W2051200733 cites W2067940206 @default.
- W2051200733 cites W2086108055 @default.
- W2051200733 cites W2098012845 @default.
- W2051200733 cites W2098972920 @default.
- W2051200733 cites W2102594196 @default.
- W2051200733 cites W2107952225 @default.
- W2051200733 cites W2125501418 @default.
- W2051200733 cites W2144508209 @default.
- W2051200733 cites W2152717709 @default.
- W2051200733 cites W2172253185 @default.
- W2051200733 cites W2336312930 @default.
- W2051200733 cites W2988868023 @default.
- W2051200733 doi "https://doi.org/10.1016/j.orthres.2003.11.009" @default.
- W2051200733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15183444" @default.
- W2051200733 hasPublicationYear "2004" @default.
- W2051200733 type Work @default.
- W2051200733 sameAs 2051200733 @default.
- W2051200733 citedByCount "99" @default.
- W2051200733 countsByYear W20512007332012 @default.
- W2051200733 countsByYear W20512007332013 @default.
- W2051200733 countsByYear W20512007332014 @default.
- W2051200733 countsByYear W20512007332015 @default.
- W2051200733 countsByYear W20512007332016 @default.
- W2051200733 countsByYear W20512007332017 @default.
- W2051200733 countsByYear W20512007332018 @default.
- W2051200733 countsByYear W20512007332019 @default.
- W2051200733 countsByYear W20512007332020 @default.
- W2051200733 countsByYear W20512007332021 @default.
- W2051200733 countsByYear W20512007332022 @default.
- W2051200733 crossrefType "journal-article" @default.
- W2051200733 hasAuthorship W2051200733A5003040527 @default.
- W2051200733 hasAuthorship W2051200733A5009550643 @default.
- W2051200733 hasAuthorship W2051200733A5017431385 @default.
- W2051200733 hasAuthorship W2051200733A5039656929 @default.
- W2051200733 hasAuthorship W2051200733A5057789441 @default.
- W2051200733 hasAuthorship W2051200733A5078398391 @default.
- W2051200733 hasBestOaLocation W20512007331 @default.
- W2051200733 hasConcept C104317684 @default.
- W2051200733 hasConcept C105702510 @default.
- W2051200733 hasConcept C153911025 @default.
- W2051200733 hasConcept C167734588 @default.
- W2051200733 hasConcept C178790620 @default.
- W2051200733 hasConcept C185592680 @default.
- W2051200733 hasConcept C202751555 @default.
- W2051200733 hasConcept C2776415932 @default.
- W2051200733 hasConcept C2777025900 @default.
- W2051200733 hasConcept C2780105995 @default.
- W2051200733 hasConcept C2780381497 @default.
- W2051200733 hasConcept C2780984734 @default.
- W2051200733 hasConcept C502942594 @default.