Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051201525> ?p ?o ?g. }
- W2051201525 endingPage "1119" @default.
- W2051201525 startingPage "1106" @default.
- W2051201525 abstract "Our previous study has revealed that heat shock protein (Hsp) 90 can interact with Sp1 to regulate the transcriptional activity of 12(S)-lipoxygenase. Herein, we further found that the interaction between Hsp90 and Sp1 occurred during mitosis. By geldanamycin (GA) treatment and knockdown of Hsp90, we found that this interaction during mitosis was involved in the maintenance of Sp1 stability, and that the phospho-c-Jun N-terminal kinase (JNK)-1 level also decreased. As the JNK-1 was knocked down by the shRNA of JNK-1, Sp1 was degraded through a ubiquitin-dependent proteasome pathway. In addition, for mutation of the JNK-1 phosphorylated residues of Sp1, namely, Sp1(T278/739A) and Sp1(T278/739D), the effect of GA on Sp1 stability was reversed. Finally, based on the involvement of Hsp90 in Sp1 stability, the transcriptional activities of p21(WAF1/CIP1) and 12(S)-lipoxygenase under GA treatment were observed to have decreased. Taken together, Hsp90 is important for maintaining Sp1 stability during mitosis by the JNK-1-mediated phosphorylation of Sp1 to enable division into daughter cells and to regulate the expression of related genes in the interphase." @default.
- W2051201525 created "2016-06-24" @default.
- W2051201525 creator A5004952365 @default.
- W2051201525 creator A5016758654 @default.
- W2051201525 creator A5017707857 @default.
- W2051201525 creator A5029092342 @default.
- W2051201525 creator A5033562862 @default.
- W2051201525 creator A5033973207 @default.
- W2051201525 creator A5045495656 @default.
- W2051201525 date "2009-04-01" @default.
- W2051201525 modified "2023-10-16" @default.
- W2051201525 title "Heat Shock Protein 90 Is Important for Sp1 Stability during Mitosis" @default.
- W2051201525 cites W1530952467 @default.
- W2051201525 cites W1622061844 @default.
- W2051201525 cites W1913069793 @default.
- W2051201525 cites W1963961667 @default.
- W2051201525 cites W1965645255 @default.
- W2051201525 cites W1967159107 @default.
- W2051201525 cites W1973570584 @default.
- W2051201525 cites W1975331444 @default.
- W2051201525 cites W1977344247 @default.
- W2051201525 cites W1979354792 @default.
- W2051201525 cites W1983665072 @default.
- W2051201525 cites W2005944430 @default.
- W2051201525 cites W2006936902 @default.
- W2051201525 cites W2014916765 @default.
- W2051201525 cites W2016334618 @default.
- W2051201525 cites W2019310947 @default.
- W2051201525 cites W2023136059 @default.
- W2051201525 cites W2025723633 @default.
- W2051201525 cites W2028321505 @default.
- W2051201525 cites W2028372355 @default.
- W2051201525 cites W2029551349 @default.
- W2051201525 cites W2032109769 @default.
- W2051201525 cites W2033039016 @default.
- W2051201525 cites W2040532363 @default.
- W2051201525 cites W2046329541 @default.
- W2051201525 cites W2046733533 @default.
- W2051201525 cites W2051793369 @default.
- W2051201525 cites W2051967461 @default.
- W2051201525 cites W2053223343 @default.
- W2051201525 cites W2053356355 @default.
- W2051201525 cites W2054438783 @default.
- W2051201525 cites W2054917615 @default.
- W2051201525 cites W2056213387 @default.
- W2051201525 cites W2060930876 @default.
- W2051201525 cites W2063914959 @default.
- W2051201525 cites W2070412642 @default.
- W2051201525 cites W2076485183 @default.
- W2051201525 cites W2079139546 @default.
- W2051201525 cites W2081085542 @default.
- W2051201525 cites W2082451220 @default.
- W2051201525 cites W2084703254 @default.
- W2051201525 cites W2088938008 @default.
- W2051201525 cites W2089126365 @default.
- W2051201525 cites W2092762008 @default.
- W2051201525 cites W2095358593 @default.
- W2051201525 cites W2106169455 @default.
- W2051201525 cites W2108966929 @default.
- W2051201525 cites W2112133866 @default.
- W2051201525 cites W2113070607 @default.
- W2051201525 cites W2130953564 @default.
- W2051201525 cites W2131472300 @default.
- W2051201525 cites W2137417707 @default.
- W2051201525 cites W2143168873 @default.
- W2051201525 cites W2146222370 @default.
- W2051201525 cites W2148601918 @default.
- W2051201525 cites W2159479890 @default.
- W2051201525 cites W2167142486 @default.
- W2051201525 cites W2324191190 @default.
- W2051201525 cites W97463986 @default.
- W2051201525 doi "https://doi.org/10.1016/j.jmb.2009.02.040" @default.
- W2051201525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19245816" @default.
- W2051201525 hasPublicationYear "2009" @default.
- W2051201525 type Work @default.
- W2051201525 sameAs 2051201525 @default.
- W2051201525 citedByCount "34" @default.
- W2051201525 countsByYear W20512015252012 @default.
- W2051201525 countsByYear W20512015252013 @default.
- W2051201525 countsByYear W20512015252014 @default.
- W2051201525 countsByYear W20512015252015 @default.
- W2051201525 countsByYear W20512015252016 @default.
- W2051201525 countsByYear W20512015252017 @default.
- W2051201525 countsByYear W20512015252019 @default.
- W2051201525 countsByYear W20512015252021 @default.
- W2051201525 countsByYear W20512015252022 @default.
- W2051201525 crossrefType "journal-article" @default.
- W2051201525 hasAuthorship W2051201525A5004952365 @default.
- W2051201525 hasAuthorship W2051201525A5016758654 @default.
- W2051201525 hasAuthorship W2051201525A5017707857 @default.
- W2051201525 hasAuthorship W2051201525A5029092342 @default.
- W2051201525 hasAuthorship W2051201525A5033562862 @default.
- W2051201525 hasAuthorship W2051201525A5033973207 @default.
- W2051201525 hasAuthorship W2051201525A5045495656 @default.
- W2051201525 hasConcept C104317684 @default.
- W2051201525 hasConcept C11960822 @default.
- W2051201525 hasConcept C1491633281 @default.
- W2051201525 hasConcept C153911025 @default.