FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W205120314> ?p ?o ?g. }

• W205120314 abstract "The aim of this research is to investigate the histological and inflammatory conjunctiva! ocular surface changes occurring in dry eye. It is anticipated that by enhancing the understanding of the components of ocular surface damage in dry eye, clinicians diagnosing and managing dry eye will be able to more specifically and effectively manage this chronic and often debilitating condition.A review of the literature indicated that traditional dry eye diagnosis and treatment has focused primarily on conditions involving aqueous tear deficiency and its autoimmune form, Sjogren's syndrome. In recent years, six subtypes of dry eye have been defined based on a revised dry eye definition of anomalies in the glands associated with tear production, the lid function and blinking mechanism and the ocular surface epithelia. A subtype based approach to dry eye diagnosis and management has been recommended. However there has been a lack of information regarding the prevalences of the various dry eye types and clinical diagnostic criteria for dry eye subtypes. Using a protocol based primarily on biomicroscopic signs, the four most prevalent dry eye conditions were found to be lipid anomaly dry eye, allergic dry eye, aqueous tear deficiency and lid surfacing anomaly dry eye. The allergic dry eye subtype was verified as being distinct from allergic conjunctivitis and other forms of dry eye on the basis of an allergic history, biomicroscopic signs and a significantly greater conjunctiva! expression of allergic inflammatory markers.The conjunctiva plays a vital role in the ocular surface integrity and corneal health. Conjunctival squamous metaplasia and the associated goblet cell loss had been reported to be a feature of dry eye and other external ocular inflammatory conditions. Previous researchers had presented evidence that immune mediated and allergic conjunctival inflammation occurring in dry eye may initiate or exacerbate the ocular surface damage. Significant increase in nucleo-cytoplasm ratio, goblet cell loss and ocular surface allergic and immune mediated inflammation were detected by histological and immunocytochemical analysis of bulbar conjunctival epithelial samples in lipid anomaly, allergic and aqueous tear deficient dry eye conditions. Nonpreserved artificial tear supplements did not improve the ocular surface histological and inflammatory status in dry eye types. Moderate use of benzalkonium chloride and/ or chlorbutanol preserved topical treatments exacerbated the ocular surface changes in dry eye subjects.Previous research in the area has found that dry eye was prevalent in contact lens wearers and pre- and post- excimer keratorefractive candidates. Conjunctival squamous metaplasia and inflammation were found to be a feature of long term contact lens wear. These ocular surface histological and inflammatory changes were found to be more significant in contact lens wearers with dry eye compared to non-dry eye contact lens wearers.Dry eye contact lens wearers undergoing excimer photorefractive keratectomy were determined to be at significantly greater risk of postoperative regression and significant subepithelial corneal haze. These individuals had significantly greater post-operative ocular surface goblet cell loss and inflammation. Pre-existing dry eye and contact lens wear did not have as significant an effect on the post-operative refractive outcome, corneal clarity, and ocular surface histology and inflammatory status in subjects undergoing the laser in situ keratomileusis procedure compared to photorefractive keratectomy procedure.Dry eye will be managed more effectively if treatment strategies can aim to restore ocular surface health rather than merely attending to symptoms. Inflammatory mechanisms in dry eye require early identification and treatment. The goblet cell density of the conjunctiva appears to be particularly sensitive to dry eye conditions associated with contact lens wear and keratorefractive surgery. Further efforts in research are required to determine agents that can effectively protect and/ or restore conjunctival goblet cells." @default.
• W205120314 created "2016-06-24" @default.
• W205120314 creator A5091770561 @default.
• W205120314 date "1999-01-01" @default.
• W205120314 modified "2023-09-26" @default.
• W205120314 title "The conjunctiva in dry eye: Histological changes, inflammation, topical treatments, contact lenses and refractive surgery" @default.
• W205120314 hasPublicationYear "1999" @default.
• W205120314 type Work @default.
• W205120314 sameAs 205120314 @default.
• W205120314 citedByCount "0" @default.
• W205120314 crossrefType "dissertation" @default.
• W205120314 hasAuthorship W205120314A5091770561 @default.
• W205120314 hasConcept C118487528 @default.
• W205120314 hasConcept C142724271 @default.
• W205120314 hasConcept C16005928 @default.
• W205120314 hasConcept C203014093 @default.
• W205120314 hasConcept C207480886 @default.
• W205120314 hasConcept C2775984611 @default.
• W205120314 hasConcept C2776882836 @default.
• W205120314 hasConcept C2776883082 @default.
• W205120314 hasConcept C2780870513 @default.
• W205120314 hasConcept C71924100 @default.
• W205120314 hasConceptScore W205120314C118487528 @default.
• W205120314 hasConceptScore W205120314C142724271 @default.
• W205120314 hasConceptScore W205120314C16005928 @default.
• W205120314 hasConceptScore W205120314C203014093 @default.
• W205120314 hasConceptScore W205120314C207480886 @default.
• W205120314 hasConceptScore W205120314C2775984611 @default.
• W205120314 hasConceptScore W205120314C2776882836 @default.
• W205120314 hasConceptScore W205120314C2776883082 @default.
• W205120314 hasConceptScore W205120314C2780870513 @default.
• W205120314 hasConceptScore W205120314C71924100 @default.
• W205120314 hasLocation W2051203141 @default.
• W205120314 hasOpenAccess W205120314 @default.
• W205120314 hasPrimaryLocation W2051203141 @default.
• W205120314 hasRelatedWork W1004172732 @default.
• W205120314 hasRelatedWork W192103936 @default.
• W205120314 hasRelatedWork W1971613309 @default.
• W205120314 hasRelatedWork W2012080029 @default.
• W205120314 hasRelatedWork W2183731652 @default.
• W205120314 hasRelatedWork W2402942245 @default.
• W205120314 hasRelatedWork W2557702725 @default.
• W205120314 hasRelatedWork W2737439597 @default.
• W205120314 hasRelatedWork W2767545295 @default.
• W205120314 hasRelatedWork W2778791553 @default.
• W205120314 hasRelatedWork W2802732911 @default.
• W205120314 hasRelatedWork W3025301899 @default.
• W205120314 hasRelatedWork W3029931763 @default.
• W205120314 hasRelatedWork W3042034567 @default.
• W205120314 hasRelatedWork W3131688980 @default.
• W205120314 hasRelatedWork W80246472 @default.
• W205120314 hasRelatedWork W802937702 @default.
• W205120314 hasRelatedWork W2101193450 @default.
• W205120314 hasRelatedWork W2833067689 @default.
• W205120314 hasRelatedWork W2931782747 @default.
• W205120314 isParatext "false" @default.
• W205120314 isRetracted "false" @default.
• W205120314 magId "205120314" @default.
• W205120314 workType "dissertation" @default.