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- W2051203642 abstract "A new anti-epileptic drug, tiagabine, is a potent inhibitor of GABA uptake into neurons and glia. Tiagabine has shown promising efficacy and safety profiles as add-on treatment for partial seizures. We evaluated the long-term effects of tiagabine on cognition and EEG in 37 patients with partial epilepsy. The study protocol consisted of a randomized, double-blind, placebo-controlled, parallel-group add-on study and an open-label extension study. During the 3 month double-blind phase at low doses (30 mg/day) tiagabine treatment did not cause any cognitive or EEG changes as compared with placebo. Tiagabine treatment did not cause deterioration in cognitive performance or produce any rhythmic slow-wave activity or other constant, new abnormalities on EEG during longer follow-up with successful treatment on higher doses after 6–12 months (mean 65.7 mg/day, range 30–80 mg/day) and after 18–24 months (mean dose 67.6 mg/day, range 24–80 mg/day). The daily dosages in the long-term follow-up of the present study are higher than in the previous reports." @default.
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- W2051203642 date "1996-11-01" @default.
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- W2051203642 title "Long-term cognitive and EEG effects of tiagabine in drug-resistant partial epilepsy" @default.
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- W2051203642 doi "https://doi.org/10.1016/s0920-1211(96)00084-8" @default.
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