FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051205523> ?p ?o ?g. }

• W2051205523 endingPage "117" @default.
• W2051205523 startingPage "111" @default.
• W2051205523 abstract "A new oral patch system has been designed to increase the residence time of model drugs within the gastrointestinal tract. The system consisted of three layers (1) water-insoluble backing layer (2) drug-carrying adhesive layer composed of a model drug, fluorescein (FL) or fluorescein isothiocyanate-dextran (FD), and gel-forming polymer and (3) pH-sensitive enteric polymer. These three layers system was prepared as 3.0 mm diameter patches. As references, tablet containing FL or FD was prepared. In vitro dissolution studies showed that the mean dissolution time (MDT) of model drugs from patch preparation was 0.739+/-0.021 h for FL and 0.407+/-0.021 h for FD, which were longer than from tablet, 0.327+/-0.008 h for FL and 0.270+/-0.019 h for FD. The two test preparations were orally administered to beagle dogs in a crossover manner at a FL dose of 30 mg/dog and the measured plasma FL concentrations were used for pharmacokinetic analysis. With FL patch preparation, area under the plasma drug concentration vs. time curve (AUC) was 2.12+/-0.24 microgh/ml and mean residence time (MRT) was 4.60+/-0.18 h, which were greater than those of tablet, AUC was 1.52+/-0.16 microgh/ml and MRT was 3.18+/-0.09 h, respectively. Oral patch preparation also increased both AUC and MRT of FD, a model macromolecular drug, which was formulated into both patches and tablets and administered to dogs (30 mg/dog). The AUC and MRT of FD from the patch preparation were 1.11+/-0.13 microgh/ml and 5.58+/-0.55 h and from tablets were 0.53+/-0.08 microg h/ml and 4.09+/-0.29 h, respectively. These results suggest that oral patch preparation has as a potential a new oral delivery system to obtain a long residence time of drug in the gastrointestinal tract." @default.
• W2051205523 created "2016-06-24" @default.
• W2051205523 creator A5028179221 @default.
• W2051205523 creator A5046220316 @default.
• W2051205523 creator A5065647386 @default.
• W2051205523 creator A5076002605 @default.
• W2051205523 creator A5086460076 @default.
• W2051205523 creator A5091761204 @default.
• W2051205523 date "2003-01-01" @default.
• W2051205523 modified "2023-10-17" @default.
• W2051205523 title "Possibility of a patch system as a new oral delivery system" @default.
• W2051205523 cites W1485145206 @default.
• W2051205523 cites W1553138080 @default.
• W2051205523 cites W1574786557 @default.
• W2051205523 cites W1968479032 @default.
• W2051205523 cites W1972157104 @default.
• W2051205523 cites W1984815101 @default.
• W2051205523 cites W1989654577 @default.
• W2051205523 cites W1992109579 @default.
• W2051205523 cites W1994265790 @default.
• W2051205523 cites W2000449667 @default.
• W2051205523 cites W2002810573 @default.
• W2051205523 cites W2003350499 @default.
• W2051205523 cites W2005807954 @default.
• W2051205523 cites W2021978496 @default.
• W2051205523 cites W2027742586 @default.
• W2051205523 cites W2045978260 @default.
• W2051205523 cites W2057402257 @default.
• W2051205523 cites W2074242464 @default.
• W2051205523 cites W2082283648 @default.
• W2051205523 cites W2084554165 @default.
• W2051205523 cites W2157746695 @default.
• W2051205523 cites W2171474756 @default.
• W2051205523 cites W2333705246 @default.
• W2051205523 cites W2335617809 @default.
• W2051205523 cites W28620972 @default.
• W2051205523 doi "https://doi.org/10.1016/s0378-5173(02)00534-3" @default.
• W2051205523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12480277" @default.
• W2051205523 hasPublicationYear "2003" @default.
• W2051205523 type Work @default.
• W2051205523 sameAs 2051205523 @default.
• W2051205523 citedByCount "30" @default.
• W2051205523 countsByYear W20512055232012 @default.
• W2051205523 countsByYear W20512055232013 @default.
• W2051205523 countsByYear W20512055232015 @default.
• W2051205523 countsByYear W20512055232016 @default.
• W2051205523 countsByYear W20512055232017 @default.
• W2051205523 countsByYear W20512055232020 @default.
• W2051205523 countsByYear W20512055232021 @default.
• W2051205523 crossrefType "journal-article" @default.
• W2051205523 hasAuthorship W2051205523A5028179221 @default.
• W2051205523 hasAuthorship W2051205523A5046220316 @default.
• W2051205523 hasAuthorship W2051205523A5065647386 @default.
• W2051205523 hasAuthorship W2051205523A5076002605 @default.
• W2051205523 hasAuthorship W2051205523A5086460076 @default.
• W2051205523 hasAuthorship W2051205523A5091761204 @default.
• W2051205523 hasConcept C112705442 @default.
• W2051205523 hasConcept C126322002 @default.
• W2051205523 hasConcept C14029885 @default.
• W2051205523 hasConcept C178790620 @default.
• W2051205523 hasConcept C185592680 @default.
• W2051205523 hasConcept C22979827 @default.
• W2051205523 hasConcept C2776820430 @default.
• W2051205523 hasConcept C2779820397 @default.
• W2051205523 hasConcept C2781430271 @default.
• W2051205523 hasConcept C43617362 @default.
• W2051205523 hasConcept C71924100 @default.
• W2051205523 hasConcept C77281830 @default.
• W2051205523 hasConcept C98274493 @default.
• W2051205523 hasConceptScore W2051205523C112705442 @default.
• W2051205523 hasConceptScore W2051205523C126322002 @default.
• W2051205523 hasConceptScore W2051205523C14029885 @default.
• W2051205523 hasConceptScore W2051205523C178790620 @default.
• W2051205523 hasConceptScore W2051205523C185592680 @default.
• W2051205523 hasConceptScore W2051205523C22979827 @default.
• W2051205523 hasConceptScore W2051205523C2776820430 @default.
• W2051205523 hasConceptScore W2051205523C2779820397 @default.
• W2051205523 hasConceptScore W2051205523C2781430271 @default.
• W2051205523 hasConceptScore W2051205523C43617362 @default.
• W2051205523 hasConceptScore W2051205523C71924100 @default.
• W2051205523 hasConceptScore W2051205523C77281830 @default.
• W2051205523 hasConceptScore W2051205523C98274493 @default.
• W2051205523 hasFunder F4320320912 @default.
• W2051205523 hasFunder F4320334764 @default.
• W2051205523 hasIssue "1" @default.
• W2051205523 hasLocation W20512055231 @default.
• W2051205523 hasLocation W20512055232 @default.
• W2051205523 hasOpenAccess W2051205523 @default.
• W2051205523 hasPrimaryLocation W20512055231 @default.
• W2051205523 hasRelatedWork W2023704986 @default.
• W2051205523 hasRelatedWork W2068318921 @default.
• W2051205523 hasRelatedWork W2069936009 @default.
• W2051205523 hasRelatedWork W2081338779 @default.
• W2051205523 hasRelatedWork W2130370136 @default.
• W2051205523 hasRelatedWork W2331297863 @default.
• W2051205523 hasRelatedWork W2365455541 @default.
• W2051205523 hasRelatedWork W2551047129 @default.
• W2051205523 hasRelatedWork W2797194040 @default.

• next