FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051205704> ?p ?o ?g. }

• W2051205704 endingPage "103" @default.
• W2051205704 startingPage "97" @default.
• W2051205704 abstract "Alterations of norepinephrine transporter (NET) function by chronic inhibition of NET in relation to sensitization to seizures induce by cocaine and local anesthetics were studied in mice. Daily administration of desipramine, an inhibitor of the NET, for 5 days decreased [(3)H]norepinephrine uptake in the P2 fractions of hippocampus but not cortex, striatum or amygdalae. Co-administration of lidocaine, bupivacaine or tricaine with desipramine reversed this effect. Daily treatment of cocaine increased [(3)H]norepinephrine uptake into the hippocampus. Daily administration of desipramine increased the incidence of appearance of lidocaine-induced convulsions and decreased that of cocaine-induced convulsions. Co-administration of lidocaine with desipramine reversed the changes of convulsive activity of lidocaine and cocaine induced by repeated administration of desipramine. These results suggest that down-regulation of hippocampal NET induced by chronic administration of desipramine may be relevant to desipramine-induced sensitization of lidocaine convulsions. Inhibition of Na(+) channels by local anesthetics may regulate desipramine-induced down-regulation of NET function. Repeated administration of cocaine induces up-regulation of hippocampal NET function. Desipramine-induced sensitization of lidocaine seizures may have a mechanism distinct from kindling resulting from repeated administration of cocaine." @default.
• W2051205704 created "2016-06-24" @default.
• W2051205704 creator A5017117731 @default.
• W2051205704 creator A5019242250 @default.
• W2051205704 creator A5021575717 @default.
• W2051205704 creator A5035698997 @default.
• W2051205704 creator A5061694354 @default.
• W2051205704 date "2006-06-01" @default.
• W2051205704 modified "2023-10-10" @default.
• W2051205704 title "Down-regulation of norepinephrine transporter function induced by chronic administration of desipramine linking to the alteration of sensitivity of local-anesthetics-induced convulsions and the counteraction by co-administration with local anesthetics" @default.
• W2051205704 cites W1522143021 @default.
• W2051205704 cites W1575803140 @default.
• W2051205704 cites W1967921751 @default.
• W2051205704 cites W1968810910 @default.
• W2051205704 cites W1973359773 @default.
• W2051205704 cites W1974771615 @default.
• W2051205704 cites W1983528715 @default.
• W2051205704 cites W1984581670 @default.
• W2051205704 cites W1987032792 @default.
• W2051205704 cites W1991639730 @default.
• W2051205704 cites W1994839919 @default.
• W2051205704 cites W1996423168 @default.
• W2051205704 cites W2000843033 @default.
• W2051205704 cites W2014706474 @default.
• W2051205704 cites W2025795470 @default.
• W2051205704 cites W2026043108 @default.
• W2051205704 cites W2026360954 @default.
• W2051205704 cites W2028772028 @default.
• W2051205704 cites W2038492841 @default.
• W2051205704 cites W2046616645 @default.
• W2051205704 cites W2047928172 @default.
• W2051205704 cites W2051352892 @default.
• W2051205704 cites W2069737416 @default.
• W2051205704 cites W2074726118 @default.
• W2051205704 cites W2080125844 @default.
• W2051205704 cites W2084634388 @default.
• W2051205704 cites W2084764099 @default.
• W2051205704 cites W2087116053 @default.
• W2051205704 cites W2087598412 @default.
• W2051205704 cites W2092643221 @default.
• W2051205704 cites W2095199220 @default.
• W2051205704 cites W2108670804 @default.
• W2051205704 cites W4232838009 @default.
• W2051205704 cites W4250562917 @default.
• W2051205704 doi "https://doi.org/10.1016/j.brainres.2006.04.033" @default.
• W2051205704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16725121" @default.
• W2051205704 hasPublicationYear "2006" @default.
• W2051205704 type Work @default.
• W2051205704 sameAs 2051205704 @default.
• W2051205704 citedByCount "12" @default.
• W2051205704 countsByYear W20512057042014 @default.
• W2051205704 crossrefType "journal-article" @default.
• W2051205704 hasAuthorship W2051205704A5017117731 @default.
• W2051205704 hasAuthorship W2051205704A5019242250 @default.
• W2051205704 hasAuthorship W2051205704A5021575717 @default.
• W2051205704 hasAuthorship W2051205704A5035698997 @default.
• W2051205704 hasAuthorship W2051205704A5061694354 @default.
• W2051205704 hasBestOaLocation W20512057042 @default.
• W2051205704 hasConcept C126322002 @default.
• W2051205704 hasConcept C170493617 @default.
• W2051205704 hasConcept C176233148 @default.
• W2051205704 hasConcept C185592680 @default.
• W2051205704 hasConcept C203014093 @default.
• W2051205704 hasConcept C2775864247 @default.
• W2051205704 hasConcept C2776217527 @default.
• W2051205704 hasConcept C2778514916 @default.
• W2051205704 hasConcept C2779177272 @default.
• W2051205704 hasConcept C2780149897 @default.
• W2051205704 hasConcept C2780250439 @default.
• W2051205704 hasConcept C2781161787 @default.
• W2051205704 hasConcept C42219234 @default.
• W2051205704 hasConcept C513476851 @default.
• W2051205704 hasConcept C71924100 @default.
• W2051205704 hasConcept C98274493 @default.
• W2051205704 hasConcept C99631742 @default.
• W2051205704 hasConceptScore W2051205704C126322002 @default.
• W2051205704 hasConceptScore W2051205704C170493617 @default.
• W2051205704 hasConceptScore W2051205704C176233148 @default.
• W2051205704 hasConceptScore W2051205704C185592680 @default.
• W2051205704 hasConceptScore W2051205704C203014093 @default.
• W2051205704 hasConceptScore W2051205704C2775864247 @default.
• W2051205704 hasConceptScore W2051205704C2776217527 @default.
• W2051205704 hasConceptScore W2051205704C2778514916 @default.
• W2051205704 hasConceptScore W2051205704C2779177272 @default.
• W2051205704 hasConceptScore W2051205704C2780149897 @default.
• W2051205704 hasConceptScore W2051205704C2780250439 @default.
• W2051205704 hasConceptScore W2051205704C2781161787 @default.
• W2051205704 hasConceptScore W2051205704C42219234 @default.
• W2051205704 hasConceptScore W2051205704C513476851 @default.
• W2051205704 hasConceptScore W2051205704C71924100 @default.
• W2051205704 hasConceptScore W2051205704C98274493 @default.
• W2051205704 hasConceptScore W2051205704C99631742 @default.
• W2051205704 hasIssue "1" @default.
• W2051205704 hasLocation W20512057041 @default.
• W2051205704 hasLocation W20512057042 @default.
• W2051205704 hasLocation W20512057043 @default.
• W2051205704 hasOpenAccess W2051205704 @default.
• W2051205704 hasPrimaryLocation W20512057041 @default.

• next