FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051206320> ?p ?o ?g. }

• W2051206320 endingPage "12108" @default.
• W2051206320 startingPage "12103" @default.
• W2051206320 abstract "Cardiac hypertrophy is accompanied by maladaptive cardiac remodeling, which leads to heart failure or sudden death. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that mediate posttranscriptional gene silencing. Recent studies show that miRNAs are involved in the pathogenesis of hypertrophy, but their signaling regulations remain to be understood. Here, we report that miR-23a is a pro-hypertrophic miRNA, and its expression is regulated by the transcription factor, nuclear factor of activated T cells (NFATc3). The results showed that miR-23a expression was up-regulated upon treatment with the hypertrophic stimuli including isoproterenol and aldosterone. Knockdown of miR-23a could attenuate hypertrophy, suggesting that miR-23a is able to convey the hypertrophic signal. In exploring the molecular mechanism by which miR-23a is up-regulated, we identified that NFATc3 could directly activate miR-23a expression through the transcriptional machinery. The muscle specific ring finger protein 1, an anti-hypertrophic protein, was identified to be a target of miR-23a. Its translation could be suppressed by miR-23a. Our data provide a model in which the miRNA expression is regulated by the hypertrophic transcriptional factor." @default.
• W2051206320 created "2016-06-24" @default.
• W2051206320 creator A5007981968 @default.
• W2051206320 creator A5011955281 @default.
• W2051206320 creator A5026044006 @default.
• W2051206320 creator A5027945126 @default.
• W2051206320 creator A5030691366 @default.
• W2051206320 creator A5046739156 @default.
• W2051206320 date "2009-07-21" @default.
• W2051206320 modified "2023-10-16" @default.
• W2051206320 title "miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy" @default.
• W2051206320 cites W144423133 @default.
• W2051206320 cites W1967686561 @default.
• W2051206320 cites W1969052554 @default.
• W2051206320 cites W1992427679 @default.
• W2051206320 cites W1993536160 @default.
• W2051206320 cites W1999943920 @default.
• W2051206320 cites W2004720912 @default.
• W2051206320 cites W2010605892 @default.
• W2051206320 cites W2034793355 @default.
• W2051206320 cites W2039144261 @default.
• W2051206320 cites W2039820053 @default.
• W2051206320 cites W2051403674 @default.
• W2051206320 cites W2055766265 @default.
• W2051206320 cites W2056675592 @default.
• W2051206320 cites W2062397694 @default.
• W2051206320 cites W2062573998 @default.
• W2051206320 cites W2075809778 @default.
• W2051206320 cites W2078381037 @default.
• W2051206320 cites W2080696342 @default.
• W2051206320 cites W2083531465 @default.
• W2051206320 cites W2084563588 @default.
• W2051206320 cites W2087224286 @default.
• W2051206320 cites W2114196012 @default.
• W2051206320 cites W2116756051 @default.
• W2051206320 cites W2118105142 @default.
• W2051206320 cites W2129439677 @default.
• W2051206320 cites W2137334802 @default.
• W2051206320 cites W2138954682 @default.
• W2051206320 cites W2142393775 @default.
• W2051206320 cites W2145242994 @default.
• W2051206320 cites W2147490295 @default.
• W2051206320 cites W2152907499 @default.
• W2051206320 cites W2153937354 @default.
• W2051206320 cites W2156433522 @default.
• W2051206320 cites W2157973267 @default.
• W2051206320 cites W2162506787 @default.
• W2051206320 cites W2317845988 @default.
• W2051206320 cites W4378618906 @default.
• W2051206320 cites W3145571634 @default.
• W2051206320 doi "https://doi.org/10.1073/pnas.0811371106" @default.
• W2051206320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2715539" @default.
• W2051206320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19574461" @default.
• W2051206320 hasPublicationYear "2009" @default.
• W2051206320 type Work @default.
• W2051206320 sameAs 2051206320 @default.
• W2051206320 citedByCount "322" @default.
• W2051206320 countsByYear W20512063202012 @default.
• W2051206320 countsByYear W20512063202013 @default.
• W2051206320 countsByYear W20512063202014 @default.
• W2051206320 countsByYear W20512063202015 @default.
• W2051206320 countsByYear W20512063202016 @default.
• W2051206320 countsByYear W20512063202017 @default.
• W2051206320 countsByYear W20512063202018 @default.
• W2051206320 countsByYear W20512063202019 @default.
• W2051206320 countsByYear W20512063202020 @default.
• W2051206320 countsByYear W20512063202021 @default.
• W2051206320 countsByYear W20512063202022 @default.
• W2051206320 countsByYear W20512063202023 @default.
• W2051206320 crossrefType "journal-article" @default.
• W2051206320 hasAuthorship W2051206320A5007981968 @default.
• W2051206320 hasAuthorship W2051206320A5011955281 @default.
• W2051206320 hasAuthorship W2051206320A5026044006 @default.
• W2051206320 hasAuthorship W2051206320A5027945126 @default.
• W2051206320 hasAuthorship W2051206320A5030691366 @default.
• W2051206320 hasAuthorship W2051206320A5046739156 @default.
• W2051206320 hasBestOaLocation W20512063201 @default.
• W2051206320 hasConcept C104317684 @default.
• W2051206320 hasConcept C119056186 @default.
• W2051206320 hasConcept C134018914 @default.
• W2051206320 hasConcept C145059251 @default.
• W2051206320 hasConcept C165864922 @default.
• W2051206320 hasConcept C167414201 @default.
• W2051206320 hasConcept C173396325 @default.
• W2051206320 hasConcept C54355233 @default.
• W2051206320 hasConcept C86339819 @default.
• W2051206320 hasConcept C86803240 @default.
• W2051206320 hasConcept C95444343 @default.
• W2051206320 hasConceptScore W2051206320C104317684 @default.
• W2051206320 hasConceptScore W2051206320C119056186 @default.
• W2051206320 hasConceptScore W2051206320C134018914 @default.
• W2051206320 hasConceptScore W2051206320C145059251 @default.
• W2051206320 hasConceptScore W2051206320C165864922 @default.
• W2051206320 hasConceptScore W2051206320C167414201 @default.
• W2051206320 hasConceptScore W2051206320C173396325 @default.
• W2051206320 hasConceptScore W2051206320C54355233 @default.
• W2051206320 hasConceptScore W2051206320C86339819 @default.
• W2051206320 hasConceptScore W2051206320C86803240 @default.

• next