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- W2051206323 abstract "Here we report a low-pressure bead packing technique for the robust integration of high-performance chromatography columns in poly(dimethylsiloxane) microfluidic devices made by multilayer soft lithography (MSL). A novel column geometry featuring micrometer-sized bypass channels along the entire length of the separation channel is used to achieve rapid packing of multiple high-quality bead bed columns in parallel with near-perfect yield. Pulse tests show that these microfluidic columns achieve exceptional reproducibility and efficiency, with measured plate counts of 1,650,000/m ± 7%, corresponding to a reduced plate height of h = 0.12 ± 7%. The combination of high-performance chromatography columns and valve-based microfluidics offers new opportunities for the integration of sample processing with preparative and analytical separations for biology and chemistry." @default.
- W2051206323 created "2016-06-24" @default.
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- W2051206323 date "2013-01-10" @default.
- W2051206323 modified "2023-09-23" @default.
- W2051206323 title "Fabrication of High-Quality Microfluidic Solid-Phase Chromatography Columns" @default.
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- W2051206323 doi "https://doi.org/10.1021/ac303153a" @default.
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