Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051208963> ?p ?o ?g. }
- W2051208963 endingPage "282" @default.
- W2051208963 startingPage "273" @default.
- W2051208963 abstract "We have developed a microarray to study the expression of L-chain V genes (V(L) genes) in healthy and SLE patient peripheral κ- and λ-sorted B cells. In all repertoires tested, one V(L) gene accounts for over 10% of all gene V(L) expression, consistent with positive selection acting on L-chains. While a few V(L) genes were highly expressed in all individuals, most V(L) genes were expressed at different levels. Some V(L) genes (5 out of a total of 78) were not detected. We attribute their absence from the repertoire to negative selection. Positive selection and negative selection were also found in SLE repertoires, but expression of V(L) genes was different; the differences point to less regulation of V(L) gene repertoires in SLE. Our data shows that V(L) gene expression is variable and supports a model where the L-chain repertoire is generated by both positive and negative selection on L-chains." @default.
- W2051208963 created "2016-06-24" @default.
- W2051208963 creator A5001563470 @default.
- W2051208963 creator A5009770000 @default.
- W2051208963 creator A5062338147 @default.
- W2051208963 date "2012-07-01" @default.
- W2051208963 modified "2023-09-25" @default.
- W2051208963 title "B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients" @default.
- W2051208963 cites W1491799051 @default.
- W2051208963 cites W1508049370 @default.
- W2051208963 cites W1514910482 @default.
- W2051208963 cites W1533561364 @default.
- W2051208963 cites W1561187831 @default.
- W2051208963 cites W1574236771 @default.
- W2051208963 cites W1692714928 @default.
- W2051208963 cites W1914609173 @default.
- W2051208963 cites W1966851529 @default.
- W2051208963 cites W1986931210 @default.
- W2051208963 cites W2001161625 @default.
- W2051208963 cites W2011940682 @default.
- W2051208963 cites W2012953012 @default.
- W2051208963 cites W2015040653 @default.
- W2051208963 cites W2017065604 @default.
- W2051208963 cites W2022486030 @default.
- W2051208963 cites W2022998640 @default.
- W2051208963 cites W2029156207 @default.
- W2051208963 cites W2033663163 @default.
- W2051208963 cites W2035772332 @default.
- W2051208963 cites W2041309682 @default.
- W2051208963 cites W2044377326 @default.
- W2051208963 cites W2047663747 @default.
- W2051208963 cites W2048137603 @default.
- W2051208963 cites W2050056264 @default.
- W2051208963 cites W2050116583 @default.
- W2051208963 cites W2064609326 @default.
- W2051208963 cites W2080117924 @default.
- W2051208963 cites W2081477822 @default.
- W2051208963 cites W2082080217 @default.
- W2051208963 cites W2082601195 @default.
- W2051208963 cites W2086672151 @default.
- W2051208963 cites W2087064593 @default.
- W2051208963 cites W2094266459 @default.
- W2051208963 cites W2098497060 @default.
- W2051208963 cites W2105029898 @default.
- W2051208963 cites W2108579454 @default.
- W2051208963 cites W2112013131 @default.
- W2051208963 cites W2112707674 @default.
- W2051208963 cites W2117789925 @default.
- W2051208963 cites W2123708888 @default.
- W2051208963 cites W2125622789 @default.
- W2051208963 cites W2126397604 @default.
- W2051208963 cites W2126879008 @default.
- W2051208963 cites W2127132484 @default.
- W2051208963 cites W2127552260 @default.
- W2051208963 cites W2134544592 @default.
- W2051208963 cites W2135151085 @default.
- W2051208963 cites W2135732733 @default.
- W2051208963 cites W2138216198 @default.
- W2051208963 cites W2144952835 @default.
- W2051208963 cites W2147600564 @default.
- W2051208963 cites W2149889928 @default.
- W2051208963 cites W2150118150 @default.
- W2051208963 cites W2150591553 @default.
- W2051208963 cites W2150740393 @default.
- W2051208963 cites W2159422758 @default.
- W2051208963 cites W2166317148 @default.
- W2051208963 cites W2166451951 @default.
- W2051208963 cites W2169410091 @default.
- W2051208963 cites W2170142229 @default.
- W2051208963 cites W2368121141 @default.
- W2051208963 cites W4313341505 @default.
- W2051208963 cites W4313347827 @default.
- W2051208963 cites W4322388507 @default.
- W2051208963 cites W46001593 @default.
- W2051208963 cites W74228490 @default.
- W2051208963 cites W93508866 @default.
- W2051208963 doi "https://doi.org/10.1016/j.molimm.2012.03.028" @default.
- W2051208963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4264353" @default.
- W2051208963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22516082" @default.
- W2051208963 hasPublicationYear "2012" @default.
- W2051208963 type Work @default.
- W2051208963 sameAs 2051208963 @default.
- W2051208963 citedByCount "14" @default.
- W2051208963 countsByYear W20512089632013 @default.
- W2051208963 countsByYear W20512089632014 @default.
- W2051208963 countsByYear W20512089632015 @default.
- W2051208963 countsByYear W20512089632016 @default.
- W2051208963 countsByYear W20512089632017 @default.
- W2051208963 countsByYear W20512089632023 @default.
- W2051208963 crossrefType "journal-article" @default.
- W2051208963 hasAuthorship W2051208963A5001563470 @default.
- W2051208963 hasAuthorship W2051208963A5009770000 @default.
- W2051208963 hasAuthorship W2051208963A5062338147 @default.
- W2051208963 hasBestOaLocation W20512089632 @default.
- W2051208963 hasConcept C104317684 @default.
- W2051208963 hasConcept C121332964 @default.
- W2051208963 hasConcept C127716648 @default.
- W2051208963 hasConcept C141231307 @default.