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- W2051209403 abstract "We have obtained a cloned cell line (Li-7A) from primary cultures of a human hepatoma xenograft (Li-7). Li-7A was able to grow in the absence of serum. Growth was stimulated 0-3 fold by addition of newborn calf serum, but was inhibited in DME/F12 media containing nine growth factors. The ectoMg2+-ATPase was 1.5-2 fold higher than the ectoCa2+-ATPase activity in cells grown in media with or without serum. In cells grown in media supplemented with the nine factors, the ectoCa2+-ATPase activity exceeded the ectoMg2+-ATPase, and there was also a 5-10 fold increase in its specific activity. Inhibition of growth was due to epidermal growth factor alone. The increased expression of the ectoCa2+-ATPase was absolutely dependent on EGF, but also required hydrocortisone and cholera toxin. The characteristics of Li-7A cells make it a suitable system for studying both the mechanism of action of EGF and plasma membrane ATPases." @default.
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- W2051209403 date "1985-01-01" @default.
- W2051209403 modified "2023-10-01" @default.
- W2051209403 title "Epidermal growth factor inhibits growth while increasing the expression of an ecto-Ca2+-ATPase of a human hepatoma cell line" @default.
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- W2051209403 doi "https://doi.org/10.1016/0006-291x(85)90564-9" @default.
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