Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051209506> ?p ?o ?g. }
- W2051209506 endingPage "1499" @default.
- W2051209506 startingPage "1493" @default.
- W2051209506 abstract "Abstract Implant particles may induce inflammatory response by activating the nuclear factor κB (NFκB) and mitogen activated protein kinases (MAPK). Previous studies have shown that these signaling pathways are involved in the transforming growth factor‐β activated kinase 1 (TAK1) in signaling cascades induced by the receptor activator of NFκB ligand (RANKL) and tumor necrosis factor‐α (TNF‐α) as well as interleukin‐1β (IL‐1β). In this study, the roles of the TAK1 pathway in the production of the pro‐inflammatory cytokine TNF‐α in RAW 264.7 cells exposed to titanium alloy particles were investigated. Endogenous TAK1 was phosphorylated upon simulating RAW 264.7 cells by titanium alloy particles. The critical role for TAK1 in p38MAPK and NFκB activation was as well confirmed by the inhibition of p38MAPK and NFκB activity following 5Z‐7‐oxozeaenol, a selective inhibitor of TAK1. Furthermore, it was found that TNF‐α was completely blocked by 5Z‐7‐oxozeaenol in RAW 264.7 cells. These results suggest that the TAK1‐MAPK‐NFκB signaling pathways may be a potential pharmacological target that can prevent instability for arthroplasty prosthesis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010" @default.
- W2051209506 created "2016-06-24" @default.
- W2051209506 creator A5004718466 @default.
- W2051209506 creator A5007709310 @default.
- W2051209506 creator A5024189712 @default.
- W2051209506 creator A5041230883 @default.
- W2051209506 creator A5063969408 @default.
- W2051209506 creator A5071515443 @default.
- W2051209506 creator A5084893043 @default.
- W2051209506 date "2009-12-14" @default.
- W2051209506 modified "2023-10-17" @default.
- W2051209506 title "Transforming growth factor-β activated kinase 1 signaling pathways regulate TNF-α production by titanium alloy particles in RAW 264.7 cells" @default.
- W2051209506 cites W1575383081 @default.
- W2051209506 cites W1966210993 @default.
- W2051209506 cites W1967311860 @default.
- W2051209506 cites W1970159959 @default.
- W2051209506 cites W1970186446 @default.
- W2051209506 cites W1977415286 @default.
- W2051209506 cites W1982123744 @default.
- W2051209506 cites W1983332596 @default.
- W2051209506 cites W1988376074 @default.
- W2051209506 cites W2000571234 @default.
- W2051209506 cites W2002649594 @default.
- W2051209506 cites W2002847372 @default.
- W2051209506 cites W2005496351 @default.
- W2051209506 cites W2008377224 @default.
- W2051209506 cites W2011230502 @default.
- W2051209506 cites W2011916426 @default.
- W2051209506 cites W2013158291 @default.
- W2051209506 cites W2017488023 @default.
- W2051209506 cites W2017838553 @default.
- W2051209506 cites W2022941999 @default.
- W2051209506 cites W2025894091 @default.
- W2051209506 cites W2029370707 @default.
- W2051209506 cites W2031037805 @default.
- W2051209506 cites W2032948190 @default.
- W2051209506 cites W2033677768 @default.
- W2051209506 cites W2033761976 @default.
- W2051209506 cites W2054973802 @default.
- W2051209506 cites W2057146036 @default.
- W2051209506 cites W2059492476 @default.
- W2051209506 cites W2074246760 @default.
- W2051209506 cites W2076885301 @default.
- W2051209506 cites W2077413589 @default.
- W2051209506 cites W2079866471 @default.
- W2051209506 cites W2082159027 @default.
- W2051209506 cites W2083821432 @default.
- W2051209506 cites W2094417687 @default.
- W2051209506 cites W2115757302 @default.
- W2051209506 cites W2119838074 @default.
- W2051209506 cites W2127823675 @default.
- W2051209506 cites W2131251938 @default.
- W2051209506 cites W2141976431 @default.
- W2051209506 cites W2143847396 @default.
- W2051209506 cites W2149122802 @default.
- W2051209506 cites W2158193380 @default.
- W2051209506 cites W2162012336 @default.
- W2051209506 cites W2245567567 @default.
- W2051209506 doi "https://doi.org/10.1002/jbm.a.32618" @default.
- W2051209506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20014292" @default.
- W2051209506 hasPublicationYear "2009" @default.
- W2051209506 type Work @default.
- W2051209506 sameAs 2051209506 @default.
- W2051209506 citedByCount "5" @default.
- W2051209506 countsByYear W20512095062016 @default.
- W2051209506 countsByYear W20512095062017 @default.
- W2051209506 countsByYear W20512095062018 @default.
- W2051209506 countsByYear W20512095062021 @default.
- W2051209506 crossrefType "journal-article" @default.
- W2051209506 hasAuthorship W2051209506A5004718466 @default.
- W2051209506 hasAuthorship W2051209506A5007709310 @default.
- W2051209506 hasAuthorship W2051209506A5024189712 @default.
- W2051209506 hasAuthorship W2051209506A5041230883 @default.
- W2051209506 hasAuthorship W2051209506A5063969408 @default.
- W2051209506 hasAuthorship W2051209506A5071515443 @default.
- W2051209506 hasAuthorship W2051209506A5084893043 @default.
- W2051209506 hasConcept C137361374 @default.
- W2051209506 hasConcept C170493617 @default.
- W2051209506 hasConcept C17991360 @default.
- W2051209506 hasConcept C184235292 @default.
- W2051209506 hasConcept C192562407 @default.
- W2051209506 hasConcept C203014093 @default.
- W2051209506 hasConcept C2777730290 @default.
- W2051209506 hasConcept C2778690821 @default.
- W2051209506 hasConcept C502942594 @default.
- W2051209506 hasConcept C55493867 @default.
- W2051209506 hasConcept C57074206 @default.
- W2051209506 hasConcept C62478195 @default.
- W2051209506 hasConcept C86803240 @default.
- W2051209506 hasConcept C88045685 @default.
- W2051209506 hasConcept C95444343 @default.
- W2051209506 hasConceptScore W2051209506C137361374 @default.
- W2051209506 hasConceptScore W2051209506C170493617 @default.
- W2051209506 hasConceptScore W2051209506C17991360 @default.
- W2051209506 hasConceptScore W2051209506C184235292 @default.
- W2051209506 hasConceptScore W2051209506C192562407 @default.
- W2051209506 hasConceptScore W2051209506C203014093 @default.
- W2051209506 hasConceptScore W2051209506C2777730290 @default.